Document Detail

Proteomics/diagnosis of chorioamnionitis and of relationships with the fetal exposome.
MedLine Citation:
PMID:  22100864     Owner:  NLM     Status:  MEDLINE    
Proteomics, a relatively young science, originally emerged as a complement to genomics research. By definition, the goal of proteomics is to provide a snapshot of all the proteins within an organism, tissue or biological sample at a given moment. Proteomics has the ability to single out one or more proteins (biomarkers) that change consistently in affected subjects as compared to those disease-free. From a proteomics perspective, chorioamnionitis poses both challenges and opportunities. Challenges relate to the dynamic course of the inflammatory process, and compartmentalization of the gestational sac in relation to the maternal compartment. An inability to evaluate the amniotic fluid non-invasively and repeatedly for meaningful changes in its proteome, and lack of a true gold standard for diagnosis of inflammation and/or infection, represent additional challenges. On the other hand, the unbiased and holistic nature of proteomics offers a real opportunity to improve the current diagnostic and prognostic algorithms for chorioamnionitis. Even at this current stage there are reasons to believe that proteomic biomarkers will improve the understanding of how chorioamnionitis programs or affects the fetus in utero, thus defining its exposome (sum of interactions between genetic make-up of the fetus and the intrauterine environment) of pregnancies affected by infection and/or inflammation. This review summarizes the results of proteomics studies that have aimed or reached these goals.
Irina A Buhimschi; Catalin S Buhimschi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-11-21
Journal Detail:
Title:  Seminars in fetal & neonatal medicine     Volume:  17     ISSN:  1878-0946     ISO Abbreviation:  Semin Fetal Neonatal Med     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2011-12-19     Completed Date:  2012-05-09     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  101240003     Medline TA:  Semin Fetal Neonatal Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  36-45     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Amniotic Fluid / chemistry,  immunology
Biological Markers / analysis
Chorioamnionitis / diagnosis*,  microbiology
Inflammation / diagnosis*,  microbiology
Pregnancy Complications, Infectious / diagnosis*,  microbiology
Proteomics / methods*
Grant Support
R01 HD047321/HD/NICHD NIH HHS; R01 HD047321-01/HD/NICHD NIH HHS; R01 HD047321-02/HD/NICHD NIH HHS; R01 HD047321-03/HD/NICHD NIH HHS; R01 HD047321-04/HD/NICHD NIH HHS; R01 HD062007/HD/NICHD NIH HHS; R01HD047321/HD/NICHD NIH HHS; R01HD062007-01/HD/NICHD NIH HHS
Reg. No./Substance:
0/Biological Markers

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