| A cholinergic antagonist, mecamylamine, blocks the phase-shifting effects of light on the circadian rhythm of locomotor activity in the golden hamster. | |
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MedLine Citation:
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PMID: 3548889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite the well known role of the light-dark cycle in the entrainment of circadian rhythms, very little is known about the neurochemical events that mediate the effects of light on the mammalian circadian clock. Recent anatomical and pharmacological data support the hypothesis that acetylcholine may be involved in relaying light-dark information from the retina to, or within, the circadian clock of rodents. If acetylcholine is required for this response, it should be possible to block the phase-shifting effects of a light pulse by blocking cholinergic neurotransmission. To test this possibility, hamsters free-running in constant darkness received an intraventricular injection of the anticholinergic drug, mecamylamine (450 micrograms), 10 min before being exposed to a 5-min pulse of light known to induce sub-maximal phase shifts in the circadian rhythm of wheel-running behavior. Compared to vehicle-injected control animals, mecamylamine treatment blocked or reduced both the phase-advancing and phase-delaying effects of light. These results support the hypothesis that acetylcholine is involved in mediating the phase-shifting effects of light on the mammalian circadian clock. |
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Authors:
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D L Keefe; D J Earnest; D Nelson; J S Takahashi; F W Turek |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 403 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1987 Feb |
Date Detail:
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Created Date: 1987-05-20 Completed Date: 1987-05-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 308-12 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Circadian Rhythm / drug effects* Cricetinae Lighting* Male Mecamylamine / pharmacology* Mesocricetus Motor Activity / drug effects* Parasympatholytics / pharmacology* Receptors, Nicotinic / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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F32 MH 09019/MH/NIMH NIH HHS; HD-09885/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Parasympatholytics; 0/Receptors, Nicotinic; 60-40-2/Mecamylamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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