| The choleretic mechanism of coumarin compounds and phenolic compounds. | |
| | |
MedLine Citation:
|
PMID: 7334456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In this work, the choleretic properties and mechanism of coumarin compounds and phenolic compounds were studied by examining their effects on parameters such as bile flow, bile acids, electrolytes, and biliary metabolites. Choleretic intensity and property of each sample was far different. The choleretic efficacy of 6, 7-dimethylesculetin (6,7-DME) was far weaker than that of 4 methylumbelliferone (4-MU). 4-hydroxybenzyl alcohol (4-HBA), isoeugenol, vanillin, paeonol, and phenolphthalein accelerated bile secretion, but 4 (B-D-glucopyranosyloxy)-benzyl alcohol, safrol, and arbutin did not. 4-MU and 4-HBA underwent conjugation in the liver to give mainly a glucuronide and their metabolites were rapidly excreted into bile, but 6, 7-DME was converted into some metabolites which were excreted little by little over a long period of time. The biliary gap between cations (NA+, K+) and anions (CL-, HCO3-, bile acids) produced after intravenous administration of 4-MU, 6, 7-DME, and 4-HBA was substantially offset by biliary concentrations of their metabolites. It was suggested that a hydroxyl group which can be mainly converted into a glucuronide is necessary in exerting a strong choleretic action. The choleretic mechanism of coumarin compounds and phenolic compounds is considered to be as follows: Their metabolites (mainly glucuronide) are actively secreted into the biliary tree as an organic anion coupled with Na+ or K+, and water is passively excreted. |
| | |
Authors:
|
S Takeda; M Aburada |
Related Documents
:
|
768646 - Sampling intestinal content with a sequestering capsule. a noninvasive technique for de... 7409386 - Bile acid output and the interdigestive migrating motor complex in normals and in chole... 2108486 - Hepatobiliary compensation for the loss of gallbladder function after cholecystectomy. ... 7852856 - Bile acid synthesis in hepg2 cells: effect of cyclosporin. 184366 - Mechanism of inhibition of organic acid transport in rabbit renal cortex by cyclic amp. 10919516 - On the fate of ingested bacillus spores. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of pharmacobio-dynamics Volume: 4 ISSN: 0386-846X ISO Abbreviation: J. Pharmacobio-dyn. Publication Date: 1981 Sep |
Date Detail:
|
Created Date: 1982-05-12 Completed Date: 1982-05-12 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7901854 Medline TA: J Pharmacobiodyn Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 724-34 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bile / drug effects, metabolism Bile Acids and Salts / analysis Cholagogues and Choleretics / pharmacology* Coumarins / metabolism, pharmacology* Electrolytes / analysis Glucuronates / metabolism Male Phenols / pharmacology* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
|
0/Bile Acids and Salts; 0/Cholagogues and Choleretics; 0/Coumarins; 0/Electrolytes; 0/Glucuronates; 0/Phenols |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Experimental atherosclerosis in rats fed a vitamin D, cholesterol-rich diet.
Next Document: Enhanced bioavailability of digoxin by gamma-cyclodextrin complexation.