| The choleretic action of clanobutin in dogs. | |
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MedLine Citation:
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PMID: 7341779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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After cannulation of the bile duct in anaesthetised dogs, clanobutin was injected intravenously. Samples were collected for periods of 15 min. Arterial and venous blood pressures as well as the electrocardiogram were recorded during the experiment. There was a slight increase in arterial and central venous pressure during the trial. Heart rate slightly decreased with a slight increase in ventricular ectopic beats. In the first 15 min after bile flow increased by 260%. The choleretic action lasted for 1,5 h. The concentration of sodium, potassium and magnesium in the bile followed a similar pattern to that of the volume. Bilirubin and calcium excretion showed a sharp increase within the first 15 min after administration. Thereafter there was a sharp drop and 30 min after administration the concentration was below the control value. |
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Authors:
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A Immelman; C Button; G Dreyer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the South African Veterinary Association Volume: 52 ISSN: 1019-9128 ISO Abbreviation: J S Afr Vet Assoc Publication Date: 1981 Dec |
Date Detail:
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Created Date: 1982-07-08 Completed Date: 1982-07-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503122 Medline TA: J S Afr Vet Assoc Country: SOUTH AFRICA |
Other Details:
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Languages: eng Pagination: 295-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / secretion* Bilirubin / metabolism Calcium / metabolism Cholagogues and Choleretics / pharmacology* Dogs / metabolism* Female Magnesium / metabolism Potassium / metabolism Sodium / metabolism gamma-Aminobutyric Acid / analogs & derivatives*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Cholagogues and Choleretics; 30544-61-7/clanobutin; 56-12-2/gamma-Aminobutyric Acid; 635-65-4/Bilirubin; 7439-95-4/Magnesium; 7440-09-7/Potassium; 7440-23-5/Sodium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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