Document Detail

The choice of a gonadotropin-releasing hormone analog influences outcome of in vitro fertilization treatment.
MedLine Citation:
PMID:  8203419     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our purpose was to determine if there is a difference in outcome associated with choice of gonadotropin-releasing hormone analog in in vitro fertilization treatment cycles. STUDY DESIGN: A retrospective analysis of 510 consecutive in vitro fertilization cycles with patient-selected use of either nafarelin (Synarel) or leuprolide (Lupron) was performed. RESULTS: Of 510 consecutive patient cycles, 284 patients (56%) chose nafarelin and 226 (44%) chose leuprolide. In the nafarelin group 64 cycles (34% of retrievals) resulted in deliveries. In the leuprolide group 37 (24%) resulted in delivery (p < 0.05). There were 260 patients in their first cycle of treatment, with 157 (60%) choosing nafarelin, resulting in 33 deliveries (34% per retrieval). Leuprolide, used in 103 (40%) of first cycles, resulted in 12 deliveries (20% per retrieval), (p = 0.052). CONCLUSIONS: In a large population of unselected patients undergoing in vitro fertilization the choice of nafarelin was associated with a significantly better outcome in terms of successful pregnancies achieved.
M C Martin; C R Givens; E D Schriock; R H Glass; P V Dandekar
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  170     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-07-07     Completed Date:  1994-07-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1629-32; discussion 1632-4     Citation Subset:  AIM; IM    
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco 94143-0132.
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MeSH Terms
Fertilization in Vitro / drug effects*
Leuprolide / therapeutic use*
Nafarelin / therapeutic use*
Ovulation Induction / methods
Retrospective Studies
Reg. No./Substance:
53714-56-0/Leuprolide; 76932-56-4/Nafarelin

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