Document Detail


The choice of a gonadotropin-releasing hormone analog influences outcome of in vitro fertilization treatment.
MedLine Citation:
PMID:  8203419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Our purpose was to determine if there is a difference in outcome associated with choice of gonadotropin-releasing hormone analog in in vitro fertilization treatment cycles. STUDY DESIGN: A retrospective analysis of 510 consecutive in vitro fertilization cycles with patient-selected use of either nafarelin (Synarel) or leuprolide (Lupron) was performed. RESULTS: Of 510 consecutive patient cycles, 284 patients (56%) chose nafarelin and 226 (44%) chose leuprolide. In the nafarelin group 64 cycles (34% of retrievals) resulted in deliveries. In the leuprolide group 37 (24%) resulted in delivery (p < 0.05). There were 260 patients in their first cycle of treatment, with 157 (60%) choosing nafarelin, resulting in 33 deliveries (34% per retrieval). Leuprolide, used in 103 (40%) of first cycles, resulted in 12 deliveries (20% per retrieval), (p = 0.052). CONCLUSIONS: In a large population of unselected patients undergoing in vitro fertilization the choice of nafarelin was associated with a significantly better outcome in terms of successful pregnancies achieved.
Authors:
M C Martin; C R Givens; E D Schriock; R H Glass; P V Dandekar
Related Documents :
1658699 - Endometrial histology and bleeding patterns after 8 years of continuous combined estrog...
8886699 - Combined use of a long-acting gonadotropin-releasing hormone agonist and low-dose danaz...
16484309 - Preventing copper intrauterine device removals due to side effects among first-time use...
14688179 - The evaluation of the effectiveness of an intrauterine-administered progestogen (levono...
2116489 - Endometriosis-associated infertility treated by long-term gonadotropin-releasing hormon...
15270209 - Parameters affecting the results in a program of artificial insemination with donor spe...
7907459 - Ondansetron, clinical development for postoperative nausea and vomiting: current studie...
14665999 - Risk factors of mortality and permanent neurologic injury in patients undergoing ascend...
10881259 - Long-term outcome in patients with guillain-barré syndrome requiring mechanical ventil...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  170     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-07-07     Completed Date:  1994-07-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1629-32; discussion 1632-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco 94143-0132.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Female
Fertilization in Vitro / drug effects*
Humans
Leuprolide / therapeutic use*
Nafarelin / therapeutic use*
Ovulation Induction / methods
Pregnancy
Retrospective Studies
Chemical
Reg. No./Substance:
53714-56-0/Leuprolide; 76932-56-4/Nafarelin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The effects of RU 486 and leuprolide acetate on uterine artery blood flow in the fibroid uterus: a p...
Next Document:  A hospital review of advanced gynecologic endoscopic procedures.