Document Detail


The choice of controls for providing validity and evidence in clinical research.
MedLine Citation:
PMID:  23018705     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Selection of controls, a group of subjects who are identical to the treatment group in all aspects that affect the outcome except the intervention of interest, is a significant criterion for conducting a study in evidence-based medical research. Few studies emphasize the appropriate selection of control groups in the plastic surgery literature.
METHODS: The authors performed a literature search in Plastic and Reconstructive Surgery from January 1, 2010, through December 31, 2011, for studies in which controls were needed. The number of studies using a control group, control selection criteria, and the characteristics of the control populations were evaluated.
RESULTS: Three hundred twenty-seven articles were obtained from our search using the keywords "case control studies" and "retrospective cohort studies." Among these studies, 121 articles were studies conducted in humans. All of these studies based on the study design required a control group, yet only 63 studies (52 percent) had a comparative control group. Of these studies, the authors found biases regarding the choice of controls, including selection bias, misclassification bias, and chronology bias.
CONCLUSIONS: The authors' review shows that 48 percent of the studies published in Plastic and Reconstructive Surgery that were required to have a control group failed to incorporate a well-defined control group. Specific details pertaining to the methods used and the success obtained with those methods in recruiting controls need to be stated explicitly in the article to ensure uniformity and to support the validity of the research.
Authors:
Sunitha Malay; Kevin C Chung
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Plastic and reconstructive surgery     Volume:  130     ISSN:  1529-4242     ISO Abbreviation:  Plast. Reconstr. Surg.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-28     Completed Date:  2012-12-14     Revised Date:  2014-10-13    
Medline Journal Info:
Nlm Unique ID:  1306050     Medline TA:  Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  959-65     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Biomedical Research*
Case-Control Studies*
Control Groups*
Female
Humans
Male
Patient Selection*
Reconstructive Surgical Procedures / methods*
Reference Values
Reproducibility of Results
Research Design
Grant Support
ID/Acronym/Agency:
2R01 AR047328-06/AR/NIAMS NIH HHS; K24 AR053120/AR/NIAMS NIH HHS; K24 AR053120/AR/NIAMS NIH HHS; R01 AR047328/AR/NIAMS NIH HHS; R01 AR062066/AR/NIAMS NIH HHS; R01 AR062066/AR/NIAMS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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