| The chlorophyll metabolite phytanic acid is a natural rexinoid--potential for treatment and prevention of diabetes. | |
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MedLine Citation:
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PMID: 11425290 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Synthetic ligands of the retinoid X receptor (RXR) have shown antidiabetic activity in mice, apparently owing to the fact that they stimulate the transcriptional activity of PPAR-gamma/RXR heterodimers, much like thiazolidinedione drugs. The chlorophyll metabolite phytanic acid has been shown to be a natural ligand for RXR, active in concentrations near its physiological levels. It is thus reasonable to suspect that phytanic acid may have utility for treatment and prevention of human type 2 diabetes. Phytanic acid may mimic or complement various effects of conjugated linoleic acids, which have been shown to activate PPAR-gamma/RXR and prevent rodent diabetes. Administration of hydrolyzed chlorophyll may represent the most cost-effective strategy for raising human tissue levels of phytanic acid. |
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Authors:
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M F McCarty |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical hypotheses Volume: 56 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-06-29 Completed Date: 2001-08-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: Scotland |
Other Details:
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Languages: eng Pagination: 217-9 Citation Subset: IM |
Affiliation:
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Pantox Laboratories, 4622 Santa Fe Street, San Diego, CA 92109, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chlorophyll / metabolism* Diabetes Mellitus, Type 2 / prevention & control* Humans Linoleic Acid / pharmacology Mice Phytanic Acid / pharmacology, therapeutic use* Receptors, Cytoplasmic and Nuclear / drug effects Transcription Factors / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Cytoplasmic and Nuclear; 0/Transcription Factors; 1406-65-1/Chlorophyll; 14721-66-5/Phytanic Acid; 2197-37-7/Linoleic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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