Document Detail


A chiral probe for the acute phase proteins alpha-1-acid glycoprotein and alpha-1-antitrypsin based on europium luminescence.
MedLine Citation:
PMID:  23023320     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Reversible and selective binding of a dynamically racemic europium(iii) complex to α(1)-acid glycoprotein and α(1)-antitrypsin is characterised by a significant change in the europium total emission spectral fingerprint and the switching on of a large circularly polarised luminescence (CPL) signal from the metal centre. Observation of an induced CD into the ligand chromophore in the presence of α(1)-AGP allows a structure for the protein-bound complex to be postulated. A direct determination of elevated α(1)-AGP levels in human serum was achieved by monitoring changes in the intensity ratio of Eu emission bands.
Authors:
Rachel Carr; Lorenzo Di Bari; Samuele Lo Piano; David Parker; Robert D Peacock; John M Sanderson
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-1
Journal Detail:
Title:  Dalton transactions (Cambridge, England : 2003)     Volume:  -     ISSN:  1477-9234     ISO Abbreviation:  Dalton Trans     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101176026     Medline TA:  Dalton Trans     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Chemistry, Durham University, South Road, Durham, DH1 3LE, UK. david.parker@durham.ac.uk.
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