| An on-chip whole blood/plasma separator with bead-packed microchannel on COC polymer. | |
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MedLine Citation:
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PMID: 20563751 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A disposable on-chip whole blood/plasma separator, which is able to separate plasma from whole human blood by capillary force through a bead-packed microchannel, has been designed, fabricated and characterized in this work. Various sizes of silica beads were slurry-packed through a microchannel using a bump structure which held beads in a defined region. The bead-packed microchannel induces a capillary force which allows plasma to move forward through the bead-packed column more rapidly than red blood cells (RBCs). The blood/plasma separator with bead-packed microchannel has successfully separated plasma from the whole blood without haemolysis of RBCs. The separation method developed in this work can be applied to various on-chip stationary filtrations of RBC for point-of-care clinical diagnostics. |
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Authors:
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Joon S Shim; Andrew W Browne; Chong H Ahn |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomedical microdevices Volume: 12 ISSN: 1572-8781 ISO Abbreviation: Biomed Microdevices Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-05 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100887374 Medline TA: Biomed Microdevices Country: United States |
Other Details:
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Languages: eng Pagination: 949-57 Citation Subset: IM |
Affiliation:
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Microsystems and BioMEMS Laboratory, Department of Electrical and Computer Engineering, University of Cincinnati, Cincinnati, OH 45221, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Specimen Collection
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instrumentation*,
methods* Cycloparaffins / chemistry* Humans Microchip Analytical Procedures / methods* Microspheres* Movement Particle Size Plasma* Point-of-Care Systems Polymers / chemistry* Silicon Dioxide / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Cycloparaffins; 0/Polymers; 7631-86-9/Silicon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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