Document Detail

On-chip spectrophotometry for bioanalysis using microring resonators.
MedLine Citation:
PMID:  21339873     Owner:  NLM     Status:  PubMed-not-MEDLINE    
We measure optical absorption in color-producing enzymatic reactions for biochemical analysis with a microscale optofluidic device. Cavity-enhanced laser spectrophotometry is performed on analytes within a microfluidic channel at visible wavelengths with silicon nitride microring resonators of 100 µm radius and quality factor of ~180,000. The resonator transmission spectrum is analyzed to determine optical absorption with a detection limit of 0.12 cm(-1). The device can be used to detect the activity of individual enzymes in a few minutes within a 100 fL sensing volume. The high sensitivity, small footprint, and low analyte consumption make absorption-based microring resonators attractive for lab-on-a-chip applications.
Arthur Nitkowski; Antje Baeumner; Michal Lipson
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Publication Detail:
Type:  Journal Article     Date:  2011-01-05
Journal Detail:
Title:  Biomedical optics express     Volume:  2     ISSN:  2156-7085     ISO Abbreviation:  Biomed Opt Express     Publication Date:  2011  
Date Detail:
Created Date:  2011-02-22     Completed Date:  2011-07-14     Revised Date:  2014-10-30    
Medline Journal Info:
Nlm Unique ID:  101540630     Medline TA:  Biomed Opt Express     Country:  United States    
Other Details:
Languages:  eng     Pagination:  271-7     Citation Subset:  -    
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