| On-chip spectrophotometry for bioanalysis using microring resonators. | |
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MedLine Citation:
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PMID: 21339873 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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We measure optical absorption in color-producing enzymatic reactions for biochemical analysis with a microscale optofluidic device. Cavity-enhanced laser spectrophotometry is performed on analytes within a microfluidic channel at visible wavelengths with silicon nitride microring resonators of 100 µm radius and quality factor of ~180,000. The resonator transmission spectrum is analyzed to determine optical absorption with a detection limit of 0.12 cm(-1). The device can be used to detect the activity of individual enzymes in a few minutes within a 100 fL sensing volume. The high sensitivity, small footprint, and low analyte consumption make absorption-based microring resonators attractive for lab-on-a-chip applications. |
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Authors:
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Arthur Nitkowski; Antje Baeumner; Michal Lipson |
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Publication Detail:
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Type: Journal Article Date: 2011-01-05 |
Journal Detail:
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Title: Biomedical optics express Volume: 2 ISSN: 2156-7085 ISO Abbreviation: Biomed Opt Express Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-22 Completed Date: 2011-07-14 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 101540630 Medline TA: Biomed Opt Express Country: United States |
Other Details:
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Languages: eng Pagination: 271-7 Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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