Document Detail


On-chip spectrophotometry for bioanalysis using microring resonators.
MedLine Citation:
PMID:  21339873     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
We measure optical absorption in color-producing enzymatic reactions for biochemical analysis with a microscale optofluidic device. Cavity-enhanced laser spectrophotometry is performed on analytes within a microfluidic channel at visible wavelengths with silicon nitride microring resonators of 100 µm radius and quality factor of ~180,000. The resonator transmission spectrum is analyzed to determine optical absorption with a detection limit of 0.12 cm(-1). The device can be used to detect the activity of individual enzymes in a few minutes within a 100 fL sensing volume. The high sensitivity, small footprint, and low analyte consumption make absorption-based microring resonators attractive for lab-on-a-chip applications.
Authors:
Arthur Nitkowski; Antje Baeumner; Michal Lipson
Related Documents :
21369263 - Analysis of optical waveguides with ultra-thin metal film based on the multidomain pseu...
2663303 - Systems dynamics in clinical pharmacokinetics. an introduction.
21164853 - Metamaterial localized resonance sensors: prospects and limitations.
Publication Detail:
Type:  Journal Article     Date:  2011-01-05
Journal Detail:
Title:  Biomedical optics express     Volume:  2     ISSN:  2156-7085     ISO Abbreviation:  Biomed Opt Express     Publication Date:  2011  
Date Detail:
Created Date:  2011-02-22     Completed Date:  2011-07-14     Revised Date:  2014-10-30    
Medline Journal Info:
Nlm Unique ID:  101540630     Medline TA:  Biomed Opt Express     Country:  United States    
Other Details:
Languages:  eng     Pagination:  271-7     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Superresolved femtosecond laser nanosurgery of cells.
Next Document:  Electric field Monte Carlo simulations of focal field distributions produced by tightly focused lase...