| The chilling details: hypoxic-ischemic encephalopathy. | |
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MedLine Citation:
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PMID: 19209061 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypoxic-ischemic encephalopathy (HIE) is one of the most important complications found in the newborn period. It is the result of a deprivation of oxygen and glucose to the neural tissue, which may be the result of either hypoxemia or ischemia. Experimental animal research and clinical observations in humans have noted that the pattern of injury occurs in 2 phases. The first phase is a primary energy failure related to the insult, and then a second energy failure occurs some hours later. The combined effects of cellular energy failure, acidosis, glutamate release, intracellular accumulation of calcium, lipid peroxidation, and nitric oxide neurotoxicity destroy essential components of the cell, culminating in cell death. The clinical presentation depends on the severity, timing, and duration of the insult, with symptoms typically evolving over approximately 72 hours. Hypothermia strategies are aimed at targeting this narrow window of opportunity to ameliorate the brain injury. |
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Authors:
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M Terese Verklan |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Journal of perinatal & neonatal nursing Volume: 23 ISSN: 1550-5073 ISO Abbreviation: J Perinat Neonatal Nurs Publication Date: 2009 Jan-Mar |
Date Detail:
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Created Date: 2009-02-11 Completed Date: 2009-05-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8801387 Medline TA: J Perinat Neonatal Nurs Country: United States |
Other Details:
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Languages: eng Pagination: 59-68; quiz 69-70 Citation Subset: N |
Affiliation:
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University of Texas Health Science Center at Houston, School of Nursing, Houston, TX 77459, USA. M.T.Verklan@uth.tmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Asphyxia Neonatorum
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complications Brain / anatomy & histology, embryology, growth & development Cerebral Hemorrhage / complications Cerebral Ventricles Early Diagnosis Fetal Development Fetal Hypoxia Fluid Therapy Humans Hypoxia-Ischemia, Brain* / diagnosis, etiology, therapy Infant, Newborn Intensive Care, Neonatal / methods* Neonatal Nursing / methods* Neurologic Examination Neuronal Plasticity Neuroprotective Agents / therapeutic use Nurse's Role Nursing Assessment Patient Discharge Risk Factors Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Neuroprotective Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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