Document Detail

A child with vitamin B12 deficiency presenting with pancytopenia and hyperpigmentation.
MedLine Citation:
PMID:  15591907     Owner:  NLM     Status:  MEDLINE    
The authors describe a 16-month-old infant presenting with neurologic developmental regression, severe pancytopenia, excessive skin pigmentation, and tremor resulting from nutritional vitamin B12 deficiency. She had been exclusively breast-fed and had refused to take any other food. Laboratory studies showed severe pancytopenia, a decrease in serum B12 levels, and an increase in urinary methylmalonic acid levels. Bone marrow aspiration was compatible with megaloblastic changes. Schilling test was normal. The serum B12 level of the mother was also low. Megaloblastic anemia resulting from inadequate B12 intake was diagnosed. Parenteral B12 therapy was initiated. The neurologic picture did not completely resolve, but pancytopenia, tremor, and hyperpigmentation of the extremities recovered completely.
Ozlem Pelin Simşek; Nazli Gönç; Fatma Gümrük; Mualla Cetin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric hematology/oncology     Volume:  26     ISSN:  1077-4114     ISO Abbreviation:  J. Pediatr. Hematol. Oncol.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-01-21     Revised Date:  2011-10-06    
Medline Journal Info:
Nlm Unique ID:  9505928     Medline TA:  J Pediatr Hematol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  834-6     Citation Subset:  IM    
Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara 06100, Turkey.
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MeSH Terms
Anemia, Megaloblastic / etiology
Hyperpigmentation / etiology*
Pancytopenia / etiology*
Treatment Outcome
Tremor / etiology
Vitamin B 12 / therapeutic use
Vitamin B 12 Deficiency / complications*
Reg. No./Substance:
68-19-9/Vitamin B 12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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