Document Detail

A chicken Wnt gene, Wnt-11, is involved in dermal development.
MedLine Citation:
PMID:  7779076     Owner:  NLM     Status:  MEDLINE    
We have isolated a new member of the Wnt gene family, Wnt-11, from chick embryo cDNA library and examined the expression pattern during embryogenesis by in situ hybridization. The Wnt-11 gene encodes Cys-rich secretory protein distantly related to Wnt-1 through Wnt-8 from the mouse and Xenopus. Expression of the Wnt-11 gene became evident at stage 14 in the dorsolateral region of somites and gradually restricted to the dermatome at stage 19 and later. In contrast to the other Wnt genes, Wnt-11 was not expressed in the neuroepithelium throughout stages 14-26. At stage 24 and later, Wnt-11 was expressed in the subectodermal mesenchyme of the limb and feather buds. The unique expression pattern of Wnt-11 in the paraxial mesoderm and dermatome suggests that Wnt-11 may play an important role in dermal development.
N Tanda; H Ohuchi; H Yoshioka; S Noji; T Nohno
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  211     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-07-10     Completed Date:  1995-07-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  123-9     Citation Subset:  IM    
Department of Pharmacology, Kawasaki Medical School, Kurashiki City, Japan.
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MeSH Terms
Amino Acid Sequence
Chick Embryo
Chickens / genetics*
Conserved Sequence
Embryonic and Fetal Development
Gene Expression
Gene Library
Molecular Sequence Data
Protein Biosynthesis
Proteins / genetics*
Sequence Homology, Amino Acid
Skin / embryology*
Wnt Proteins
Xenopus Proteins
Xenopus laevis
Reg. No./Substance:
0/Glycoproteins; 0/Proteins; 0/Wnt Proteins; 0/Xenopus Proteins; 0/wnt-11 protein, Xenopus

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