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A chicken RAD51 homologue is expressed at high levels in lymphoid and reproductive organs.
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MedLine Citation:
PMID:  8479908     Owner:  NLM     Status:  MEDLINE    
Comparisons of the amino acid sequences of three yeast RecA-like proteins, Rad51 and DMC1 from S.cerevisiae and Rad51 from S.pombe, revealed several highly conserved regions. Degenerated oligonucleotides encoding two of these regions were used for the polymerase chain reaction to clone a chicken RecA-like gene. The encoded protein shares 68% and 49% identical amino acids with the Rad51 and DMC1 proteins. The strong sequence conservation between the yeast and chicken genes indicates that RecA homologues are conserved throughout evolution from prokaryotes to higher eukaryotes. High expression of the chicken Rad51 gene was found within the organs of lymphoid and germ cell development suggesting its involvement in lymphoid and meiotic recombination.
O Bezzubova; A Shinohara; R G Mueller; H Ogawa; J M Buerstedde
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nucleic acids research     Volume:  21     ISSN:  0305-1048     ISO Abbreviation:  Nucleic Acids Res.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-05-25     Completed Date:  1993-05-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0411011     Medline TA:  Nucleic Acids Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1577-80     Citation Subset:  IM    
Basel Institute for Immunology, Switzerland.
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MeSH Terms
Amino Acid Sequence
Avian Proteins
Base Sequence
Chickens / genetics,  immunology
Cloning, Molecular
DNA-Binding Proteins / genetics*
Genitalia / chemistry
Lymphoid Tissue / chemistry
Meiosis / genetics*
Molecular Sequence Data
Rad51 Recombinase
Rec A Recombinases / genetics
Recombination, Genetic / genetics*
Saccharomyces cerevisiae Proteins
Sequence Homology, Amino Acid
Reg. No./Substance:
0/Avian Proteins; 0/DNA-Binding Proteins; 0/Saccharomyces cerevisiae Proteins; EC 2.7.7.-/RAD51 protein, Gallus gallus; EC 2.7.7.-/RAD51 protein, S cerevisiae; EC 2.7.7.-/Rad51 Recombinase; EC 2.7.7.-/Rec A Recombinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Nucleic Acids Res
ISSN: 0305-1048
ISSN: 1362-4962
Article Information
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Print publication date: Day: 11 Month: 4 Year: 1993
Volume: 21 Issue: 7
First Page: 1577 Last Page: 1580
ID: 309365
PubMed Id: 8479908

A chicken RAD51 homologue is expressed at high levels in lymphoid and reproductive organs.
O Bezzubova
A Shinohara
R G Mueller
H Ogawa
J M Buerstedde
Basel Institute for Immunology, Switzerland.

Article Categories:
  • Research Article

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