| A chemotactic inhibitory factor in the minimal change nephrotic syndrome. | |
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MedLine Citation:
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PMID: 3818178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study attempts to investigate the role of neutrophil in the increased incidence of infection in nephrotic syndrome. We investigated the function of neutrophils in the various categories of nephritis and the relationship to the response of steroid therapy in the nephrotic syndrome. We used peripheral blood for the study of chemotaxis in 62 children suffering from nephritis in the acute phase and in remission. These patients included minimal change nephrotic syndrome (9 cases), focal segmental glomerular sclerosis (3 cases), mesangial cell proliferative nephropathy (23 cases), Hepatitis B antigenemia associated membranous glomerulonephropathy (4 cases), poststreptococcal glomerulonephritis (20 cases) and chronic glomerulonephritis (3 cases). The chemotactic index was significantly increased in normal range in the remission stage. The molecular weight of the chemotactic inhibitory factor was estimated to be about 89,000 using Sephacryl S-200 column. All cases of mesangial proliferative nephropathy had nephrotic syndrome with frequent relapses or steroid resistance. These results suggest that the chemotactic index may serve as an important parameter between steroid responsive and non-responsive nephrotic syndrome. |
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Authors:
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C Y Lin; S N Su |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The International journal of pediatric nephrology Volume: 7 ISSN: 0391-6510 ISO Abbreviation: Int J Pediatr Nephrol Publication Date: 1986 Oct-Dec |
Date Detail:
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Created Date: 1987-04-23 Completed Date: 1987-04-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8007162 Medline TA: Int J Pediatr Nephrol Country: ITALY |
Other Details:
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Languages: eng Pagination: 191-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Chemotactic Factors / antagonists & inhibitors* Chemotaxis, Leukocyte* Child Child, Preschool Chronic Disease Female Glomerulonephritis / blood Glomerulosclerosis, Focal Segmental / blood Humans Infant Lymphokines / blood* Male Nephrosis, Lipoid / blood* Neutrophils / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Chemotactic Factors; 0/Lymphokines; 0/chemotactic inhibitory factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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