| The chemokine SDF-1 regulates blastema formation during zebrafish fin regeneration. | |
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MedLine Citation:
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PMID: 16586100 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The work presented in this study focuses on blastema formation in epimorphic regeneration. We describe the expression pattern of Sdf1a and Sdf1b (the chemokines stromal-cell-derived factor-1a and 1b) and their two receptors Cxcr4a and Cxcr4b during zebrafish fin regeneration. We demonstrate that Sdf1a/Cxcr4a plays a critical role in fin regeneration and more precisely in epidermal cell proliferation, an important process for blastema formation. In mammals, a single cxcr4 gene is involved both in chemotaxis and cell proliferation and survival; we discuss in this study a possible functional division of the two cxcr4 zebrafish genes. |
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Authors:
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Pascale Dufourcq; Sophie Vriz |
Publication Detail:
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Type: Journal Article Date: 2006-04-04 |
Journal Detail:
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Title: Development genes and evolution Volume: 216 ISSN: 0949-944X ISO Abbreviation: Dev. Genes Evol. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-22 Completed Date: 2007-01-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9613264 Medline TA: Dev Genes Evol Country: Germany |
Other Details:
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Languages: eng Pagination: 635-9 Citation Subset: IM |
Affiliation:
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UFR de Biologie, Université Paris 7-Denis Diderot, 2 pl. Jussieu, 75005, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemokines, CXC / physiology* In Situ Hybridization Regeneration* Zebrafish / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Chemokines, CXC |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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