Document Detail

A chemical study on the development of the human forebrain and cerebellum during the brain 'growth spurt' period. I. Gangliosides and plasmalogens.
MedLine Citation:
PMID:  728805     Owner:  NLM     Status:  MEDLINE    
Following upon previous studies on the lipid composition of the developing human brain, a further study is presented with the main object of tracing the chemical changes underlying the period of brain 'growth spurt'. Gangliosides and plasmalogens were selected as approximate markers of synaptogenesis and myelination, respectively, and these lipids were compared in cerebrum and cerebellum to establish the time, if any, at which their rate of accretion increases in a significant way. In the forebrain the rate of increase in concentration of these lipids accelerated at about the 32nd week of gestational age. Although there were too few postnatal cases to draw very firm conclusions, it seemed that the ganglioside concentration levelled off at about two months postnatal age and that the plasmalogen concentration reached a plateau between the 4th and the 6th postnatal months. In the cerebellum the concentration of gangliosides was clearly lower than that in the forebrain until about one year of age, the maximum rate of increase occurring between the last weeks of gestation and the second postnatal month. The plasmalogen concentration was somewhat higher in the cerebellum than in the forebrain but the concentration profile was similar to that followed by the gangliosides. In clear contrast with the concentration profiles in the cerebrum, in the cerebellum both lipids apparently continued to increase up to the second postnatal year. A mainly perinatal period of vulnerability is suggested for the forebrain, and a more prolonged one (probably until the second year of life) for the cerebellum.
M Martínez; A Ballabriga
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research     Volume:  159     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  351-62     Citation Subset:  IM    
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MeSH Terms
Cerebellum / growth & development*,  metabolism
Diencephalon / growth & development*,  metabolism
Gangliosides / metabolism*
Gestational Age
Infant, Newborn
Myelin Sheath / metabolism
Plasmalogens / metabolism*
Synapses / metabolism
Telencephalon / growth & development*,  metabolism
Reg. No./Substance:
0/Gangliosides; 0/Plasmalogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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