Document Detail

The chemical structure of bacterial endotoxin in relation to bioactivity.
MedLine Citation:
PMID:  8330896     Owner:  NLM     Status:  MEDLINE    
Lipopolysaccharides (LPS) constitute the O-antigens and endotoxins of Gram-negative bacteria. Whereas both the polysaccharide and lipid portion of LPS contribute to the pathogenic potential of this class of bacteria, it is the lipid component (lipid A) which determines the endotoxic properties of LPS. The primary structure of lipid A of various bacterial origin has been elucidated and Escherichia coli lipid A has been chemically synthesized. The biological analysis of synthetic lipid A partial structures proved that the expression of endotoxic activity depends on a unique structural arrangement and conformation. Such analyses have furthermore provided insight into the determinants required for lipid A binding to and activation of human target cells. Present research efforts aim at the molecular characterization of the specificity, modulation and biomedical consequences of the interaction of lipid A with host cells.
E T Rietschel; T Kirikae; F U Schade; A J Ulmer; O Holst; H Brade; G Schmidt; U Mamat; H D Grimmecke; S Kusumoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunobiology     Volume:  187     ISSN:  0171-2985     ISO Abbreviation:  Immunobiology     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-08-19     Completed Date:  1993-08-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8002742     Medline TA:  Immunobiology     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  169-90     Citation Subset:  IM    
Forschungsinstitut Borstel, Institut für Experimentelle Biologie und Medizin, Germany.
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MeSH Terms
Carbohydrate Sequence
Endotoxins / chemistry*,  physiology
Escherichia coli / chemistry
Gram-Negative Bacteria / chemistry*,  physiology
Lipid A / chemical synthesis,  chemistry
Lipopolysaccharides / chemistry
Molecular Sequence Data
Oligosaccharides / chemistry
Structure-Activity Relationship
Reg. No./Substance:
0/Endotoxins; 0/Lipid A; 0/Lipopolysaccharides; 0/Oligosaccharides

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