Document Detail

The chemical reactions in the human stomach and the relationship to metabolic disorders.
MedLine Citation:
PMID:  15823700     Owner:  NLM     Status:  MEDLINE    
Acid hydrolysis of components from the diet in the stomach require the presence of an acid and a hydrolysing agent. The acid involved is hydrochloric acid. The present mechanism of hydrochloric acid production in the stomach is demonstrated to be incompatible with measured intracellular or intercellular concentrations of the relevant ions. An alternative set of chemical reactions whereby hydrochloric acid is formed in the stomach is presented. The hydrolysing agent is identified and a mechanism of transfer of chemical compounds into the metabolism is described. The hypothesis demonstrates that some of chemical compounds produced in the stomach can induce conditions such as asthma and that the conditions of osteoporosis and hemochromatosis can be linked to the function of the stomach. Possible treatments for these and other conditions such as stomach acidity and anaemia are proposed.
D S Robertson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  64     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2005  
Date Detail:
Created Date:  2005-04-12     Completed Date:  2005-09-30     Revised Date:  2013-04-05    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  1127-31     Citation Subset:  IM    
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MeSH Terms
Ammonia / metabolism
Antacids / therapeutic use
Asthma / etiology
Bicarbonates / therapeutic use
Calcium Chloride / metabolism
Calcium Phosphates / metabolism
Digestion / physiology*
Ferric Compounds / metabolism*
Ferrous Compounds / therapeutic use
Gastric Acid / metabolism*,  secretion
Gastric Juice / metabolism*
Gastric Mucosa / secretion
Gastritis / metabolism,  microbiology
Gastrointestinal Contents
Helicobacter Infections / metabolism
Helicobacter pylori / metabolism
Hemochromatosis / etiology
Ion Transport
Metabolic Diseases / etiology*
Models, Biological*
Models, Chemical
Nitrous Oxide / metabolism
Osteoporosis / etiology
Parietal Cells, Gastric / metabolism
Sodium Bicarbonate / metabolism
Stomach / metabolism*,  microbiology
Reg. No./Substance:
0/Antacids; 0/Bicarbonates; 0/Calcium Phosphates; 0/Chlorides; 0/Ferric Compounds; 0/Ferrous Compounds; 0/ferrous bicarbonate; 10024-97-2/Nitrous Oxide; 10043-52-4/Calcium Chloride; 1309-37-1/ferric oxide; 144-55-8/Sodium Bicarbonate; 7664-41-7/Ammonia; 97Z1WI3NDX/calcium phosphate; U38V3ZVV3V/ferric chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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