| The chemical reactions in the human stomach and the relationship to metabolic disorders. | |
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MedLine Citation:
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PMID: 15823700 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acid hydrolysis of components from the diet in the stomach require the presence of an acid and a hydrolysing agent. The acid involved is hydrochloric acid. The present mechanism of hydrochloric acid production in the stomach is demonstrated to be incompatible with measured intracellular or intercellular concentrations of the relevant ions. An alternative set of chemical reactions whereby hydrochloric acid is formed in the stomach is presented. The hydrolysing agent is identified and a mechanism of transfer of chemical compounds into the metabolism is described. The hypothesis demonstrates that some of chemical compounds produced in the stomach can induce conditions such as asthma and that the conditions of osteoporosis and hemochromatosis can be linked to the function of the stomach. Possible treatments for these and other conditions such as stomach acidity and anaemia are proposed. |
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Authors:
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D S Robertson |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical hypotheses Volume: 64 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 2005 |
Date Detail:
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Created Date: 2005-04-12 Completed Date: 2005-09-30 Revised Date: 2013-04-05 |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: Scotland |
Other Details:
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Languages: eng Pagination: 1127-31 Citation Subset: IM |
Affiliation:
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kao.34@dial.pipex.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Ammonia / metabolism Antacids / therapeutic use Asthma / etiology Bicarbonates / therapeutic use Calcium Chloride / metabolism Calcium Phosphates / metabolism Chlorides Digestion / physiology* Ferric Compounds / metabolism* Ferrous Compounds / therapeutic use Gastric Acid / metabolism*, secretion Gastric Juice / metabolism* Gastric Mucosa / secretion Gastritis / metabolism, microbiology Gastrointestinal Contents Helicobacter Infections / metabolism Helicobacter pylori / metabolism Hemochromatosis / etiology Humans Hydrolysis Ion Transport Metabolic Diseases / etiology* Models, Biological* Models, Chemical Nitrous Oxide / metabolism Osteoporosis / etiology Parietal Cells, Gastric / metabolism Sodium Bicarbonate / metabolism Stomach / metabolism*, microbiology |
| Chemical | |
Reg. No./Substance:
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0/Antacids; 0/Bicarbonates; 0/Calcium Phosphates; 0/Chlorides; 0/Ferric Compounds; 0/Ferrous Compounds; 0/ferrous bicarbonate; 10024-97-2/Nitrous Oxide; 10043-52-4/Calcium Chloride; 1309-37-1/ferric oxide; 144-55-8/Sodium Bicarbonate; 7664-41-7/Ammonia; 97Z1WI3NDX/calcium phosphate; U38V3ZVV3V/ferric chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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