| The chemical and physical characteristics of single-walled carbon nanotube film impact on osteoblastic cell response. | |
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MedLine Citation:
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PMID: 20622299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carbon-nanotube-based substrates have been shown to support the growth of different cell types and, as such, have raised considerable interest in view of their possible use in biomedical applications. Nanotube matrices are embedded in polymers which cause inherent changes in nanotube chemical and physical film properties. Thus, it is critical to understand how the physical properties of the film affect the biology of the host tissue. Here, we investigated how the physical and chemical properties of single-walled carbon nanotubes (SWNT) films impact the response of MC3T3-E1 bone osteoblasts. We found that two fundamental steps in cell growth-initial attachment to the substrate and proliferation-are strongly dependent on, respectively, the energy and roughness of the surface. Thus, fine-tuning the properties of the film may represent a valid strategy to optimize the response of the biological host. |
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Authors:
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Wojtek Tutak; Manish Chhowalla; Federico Sesti |
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Publication Detail:
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Type: Journal Article Date: 2010-07-12 |
Journal Detail:
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Title: Nanotechnology Volume: 21 ISSN: 1361-6528 ISO Abbreviation: Nanotechnology Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-16 Completed Date: 2010-10-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101241272 Medline TA: Nanotechnology Country: England |
Other Details:
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Languages: eng Pagination: 315102 Citation Subset: IM |
Affiliation:
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Materials Science and Engineering, School of Engineering Rutgers, State University of New Jersey, Piscataway, NJ 08854, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Adhesion Cell Line Cell Proliferation Nanotubes, Carbon / chemistry*, ultrastructure Osteoblasts / cytology* Surface Properties |
| Chemical | |
Reg. No./Substance:
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0/Nanotubes, Carbon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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