Document Detail


The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure.
MedLine Citation:
PMID:  21237159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exposure of cell lines endogenously expressing the thyroid hormone activating enzyme type 2 deiodinase (D2) to the chemical chaperones tauroursodeoxycholic acid (TUDCA) or 4-phenylbutiric acid (4-PBA) increases D2 expression, activity and T3 production. In brown adipocytes, TUDCA or 4-PBA induced T3-dependent genes and oxygen consumption (∼2-fold), an effect partially lost in D2 knockout cells. In wild type, but not in D2 knockout mice, administration of TUDCA lowered the respiratory quotient, doubled brown adipose tissue D2 activity and normalized the glucose intolerance associated with high fat feeding. Thus, D2 plays a critical role in the metabolic effects of chemical chaperones.
Authors:
Wagner S da-Silva; Scott Ribich; Rafael Arrojo e Drigo; Melany Castillo; Mary-Elizabeth Patti; Antonio C Bianco
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-01-14
Journal Detail:
Title:  FEBS letters     Volume:  585     ISSN:  1873-3468     ISO Abbreviation:  FEBS Lett.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-31     Completed Date:  2011-03-17     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  539-44     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Affiliation:
Division of Endocrinology, Diabetes, and Metabolism, University of Miami Miller School of Medicine, Miami, FL 33143, USA.
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MeSH Terms
Descriptor/Qualifier:
Adipocytes, Brown / drug effects,  metabolism
Animals
Cell Line
Cells, Cultured
Dietary Fats / adverse effects
Energy Metabolism / drug effects*
Gene Expression Regulation / drug effects
Gene Knockout Techniques
Glucose Intolerance / prevention & control
Humans
Iodide Peroxidase / genetics,  metabolism*
Lipid Metabolism / drug effects
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Oxygen Consumption / drug effects
Phenylbutyrates / pharmacology*
RNA, Messenger / metabolism
Taurochenodeoxycholic Acid / pharmacology*
Triiodothyronine / metabolism*
Grant Support
ID/Acronym/Agency:
DK65055/DK/NIDDK NIH HHS; R01 DK065055-05/DK/NIDDK NIH HHS; R01 DK065055-07/DK/NIDDK NIH HHS; R01 DK077148-04/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Phenylbutyrates; 0/RNA, Messenger; 516-35-8/Taurochenodeoxycholic Acid; 60EUX8MN5X/tauroursodeoxycholic acid; 6893-02-3/Triiodothyronine; 7WY7YBI87E/4-phenylbutyric acid; EC 1.11.1.-/iodothyronine deiodinase type II; EC 1.11.1.8/Iodide Peroxidase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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