| The chemical biology of aptamers. | |
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MedLine Citation:
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PMID: 19319884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aptamers are small single-stranded nucleic acids that fold into a well-defined three-dimensional structure. They show a high affinity and specificity for their target molecules and inhibit their biological functions. Aptamers belong to the nucleic acids family and can be synthesized by chemical or enzymatic procedures, or a combination of the two. They can, therefore, be considered as both chemical and biological substances. This Review summarizes the most convenient approaches to their preparation and new developments in the field of aptamers. The application of aptamers in chemical biology is also discussed. |
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Authors:
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Günter Mayer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Angewandte Chemie (International ed. in English) Volume: 48 ISSN: 1521-3773 ISO Abbreviation: Angew. Chem. Int. Ed. Engl. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-03-30 Completed Date: 2009-05-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370543 Medline TA: Angew Chem Int Ed Engl Country: Germany |
Other Details:
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Languages: eng Pagination: 2672-89 Citation Subset: IM |
Affiliation:
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Life and Medical Sciences, Prog. Unit Chemical Biology and Medicinal Chemistry, University of Bonn c/o Kekulé-Institute for Organic Chemistry and Biochemistry, Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany. gmayer@uni-bonn.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aptamers, Nucleotide
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chemical synthesis,
chemistry*,
diagnostic use Drug Carriers Drug Discovery Fluorescent Dyes / chemistry Oligonucleotides / chemistry Pharmaceutical Preparations / chemistry RNA Interference SELEX Aptamer Technique |
| Chemical | |
Reg. No./Substance:
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0/Aptamers, Nucleotide; 0/Drug Carriers; 0/Fluorescent Dyes; 0/Oligonucleotides; 0/Pharmaceutical Preparations |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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