Document Detail


Histological/biological characterization of decellularized bovine jugular vein.
MedLine Citation:
PMID:  17387188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several deficiencies in currently available right ventricular valved conduits make them problematic for use in infants and children. A solution would be to develop a tissue-engineered valved conduit containing autologous cells. A method was devised to produce a decellularized bovine matrix scaffold for developing a tissue-engineered right ventricular valved conduit. Fresh bovine jugular veins were treated with sodium deoxycholate and Triton X-100. The major structural proteins of the fresh and decellularized jugular venous valves and vessel walls were detected by histological methods. Thickness, water absorption rate, water maintenance rate, disruption strength, and extensibility were determined. Circumferential and radial specimens of valves and vessel walls were subjected to tensile testing. Histological analysis showed that no cell fragments were retained within the decellularized matrix scaffold and the major structural proteins had been retained intact. There were no significant differences in thickness, rates of absorption and maintenance of water, disruption strength, and extensibility between the decellularized and fresh veins. It was concluded that this treatment can successfully remove cellular components while maintaining the major structural components and the histological and biological properties of bovine jugular veins.
Authors:
Wu Li; Wei-Yong Liu; Ding-Hua Yi; Shi-Qiang Yu; Zhen-Xiao Jin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian cardiovascular & thoracic annals     Volume:  15     ISSN:  1816-5370     ISO Abbreviation:  Asian Cardiovasc Thorac Ann     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-27     Completed Date:  2008-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9503417     Medline TA:  Asian Cardiovasc Thorac Ann     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  91-6     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xian, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cardiac Surgical Procedures
Cattle
Heart Ventricles / surgery*
Jugular Veins / pathology*
Tissue Engineering*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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