| The characteristics of the staircase phenomenon during the period of twitch stabilization in infants in TOF mode. | |
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MedLine Citation:
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PMID: 23072260 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Acceleromyography used to monitor the neuromuscular transmission function is available in infants and children. However, information on the so-called staircase phenomenon during the baseline stabilization period in this population is limited. Our objective was to assess the characteristics of such phenomenon in infants in acceleromyography. METHODS: Thirty infants were divided into three groups: group A (aged 1-5 months, n = 10), group B (aged 6-11 months, n = 10), and group C (aged 12-24 months, n = 10). Anesthesia was induced and maintained without neuromuscular blocking agents. Patients received a supramaximal stimulus followed by TOF measurements every 15 s over the course of 30 min with a TOF-Watch(®) SX. All data were collected in a notebook computer using the TOF-Watch(®) SX Monitor software through optical fibers. RESULTS: The evoked T(1) responses in younger infants (group A) were significantly lower than those in older infants (groups B and C) from 0-20 min. In group A, the signals increased to the maximum value of 121 ± 15% that of the control at 7.25 min and decreased toward a plateau of 113 ± 18% at 30 min. In group B, the signal heights increased to the maximum value of 143 ± 14% at 9.5 min, then decreased slowly to 136 ± 10% at 19.5 min, finally reaching 116 ± 12% at 30 min. In group C, the mean values of T(1) reached the maximum of 139 ± 19% that of control at 9.5 min and finally reached 126 ± 22% of control at 30 min. CONCLUSIONS: The staircase effect presents in a shorter time course and at lower degrees in smaller infants. However, in older infants, staircase effect still presents in a long period and may influence the onset time and duration of twitch depression after muscle relaxants administration. |
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Authors:
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Zhi-Jian Zhou; Xuan Wang; Shan Zheng; Xue-Feng Zhang; Jerrold Lerman |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-17 |
Journal Detail:
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Title: Paediatric anaesthesia Volume: - ISSN: 1460-9592 ISO Abbreviation: Paediatr Anaesth Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9206575 Medline TA: Paediatr Anaesth Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Blackwell Publishing Ltd. |
Affiliation:
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Department of Anesthesiology, Children's Hospital of Fudan University, ShangHai, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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