Document Detail


The characteristics of respiratory function and pulmonary hemodynamics in patients with portal hypertension.
MedLine Citation:
PMID:  22257475     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE:   To investigate the respiratory function and pulmonary hemodynamics in patients with portal hypertension (PHT).
METHODS:   A total of 148 patients with PHT were divided into three groups according to Child-Pugh classification. Results of blood biochemistry test, lung function test, arterial blood gas analysis, free portal pressure (FPP) and pulmonary hemodynamics measurements of the three Child-Pugh grade groups were compared with those of the control group.
RESULTS:   The overall incidence of arterial hypoxemia was 27.0% in PHT patients. Arterial oxygen tension (PaO(2) ) had a significant negative correlation with FPP (r = -0.76, P < 0.01) and Child-Pugh grade (r = -0.42, P < 0.01), as well as a positive correlation with systemic vascular resistance (SVR, r = 0.24, P = 0.01). Alveolar-arterial oxygen difference (A-aDO(2) ) increased in Child-Pugh grade C group when compared with Child-Pugh grade A and B groups (P < 0.05). Restrictive impairment of lung function was seen in Child-Pugh grade C group. Direct measurement of the hemodynamics in PHT patients revealed a hyperdynamic disturbance in both systemic and portal venous systems, and was illustrated in pulmonary circulation as an increase of mean pulmonary arterial pressure (MPAP) and pulmonary arterial wedged pressure (PAWP) as well as a decrease of pulmonary vascular resistance (PVR).
CONCLUSIONS:   High output and low resistance are the key characteristics of pulmonary circulation in PHT patients and the decrease of PVR can be detected even when liver function is still compensated.
Authors:
Yong Wei Sun; Rong Hua; Yan Miao Huo; Hui Cao; Zhi Yong Wu; Meng Luo; Qing Xu; Wei Chen; Xian Ming Kong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of digestive diseases     Volume:  13     ISSN:  1751-2980     ISO Abbreviation:  J Dig Dis     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101302699     Medline TA:  J Dig Dis     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  75-81     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd.
Affiliation:
Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine Department of Stem Cell Clinical Research Center, Med-X Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
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