Document Detail

The characteristics of postcountershock pulseless electrical activity may indicate the outcome of CPR.
MedLine Citation:
PMID:  16459008     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: When ventricular fibrillation is cardioverted to pulseless electrical activity (PEA), PEA has been regarded as a non-resuscitatable rhythm. Yet, recent reports and our earlier observations suggested otherwise. We therefore investigated outcomes after postcountershock PEA, and aimed to develop a scoring system for outcome classification at the onset of initial postcountershock PEA. METHODS: Data from 215 domestic pigs were retrospectively reviewed. VF was induced and untreated for 7 min. Defibrillation was attempted with up to three 150 J biphasic shocks. Failing to restore spontaneous circulation (ROSC), 1 min of CPR preceded subsequent sequences of shocks until animals were resuscitated or for a total of 15 min. Fifty-nine instances of PEA followed defibrillation, including 29 animals that attained ROSC. RESULTS: ROSC animals required a shorter interval between the first shock and the initial postcountershock PEA, fewer shocks prior to onset of initial postcountershock PEA, demonstrated a greater VF wavelet amplitude prior to onset of initial PEA, smaller QRS intervals, and higher heart rates. Using Fisher's linear discriminant analysis, 79.3% of the ROSC and 63.3% of non-ROSC cases were predicted correctly. A total of 71.2% of all cases were classified correctly. CONCLUSIONS: Animals in which postcountershock PEA was converted to ROSC required shorter intervals from first shock to initial postcountershock PEA, fewer shocks prior to onset of initial postcountershock PEA, had greater VF wavelet amplitude prior to initial postcountershock PEA, small QRS intervals, and higher heart rates. Fisher's discriminant analysis is helpful in predicting the likelihood of ROSC for an individual animal presenting with postcountershock PEA.
Xiangshao Fang; Wanchun Tang; Shijie Sun; Jinglan Wang; Lei Huang; Max Harry Weil
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-02-03
Journal Detail:
Title:  Resuscitation     Volume:  69     ISSN:  0300-9572     ISO Abbreviation:  Resuscitation     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-02     Completed Date:  2006-10-31     Revised Date:  2009-08-25    
Medline Journal Info:
Nlm Unique ID:  0332173     Medline TA:  Resuscitation     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  303-9     Citation Subset:  IM    
Weil Institute of Critical Care Medicine, 35100 Bob Hope Drive, Rancho Mirage, CA, USA.
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MeSH Terms
Blood Circulation / physiology
Cardiopulmonary Resuscitation / methods*
Discriminant Analysis
Disease Models, Animal
Electric Countershock*
Heart Arrest / etiology,  therapy*
Retrospective Studies
Ventricular Fibrillation / physiopathology,  therapy*

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