Document Detail

The characteristics and mechanisms of visual disturbance associated with anticonvulsant therapy.
MedLine Citation:
PMID:  2330106     Owner:  NLM     Status:  MEDLINE    
Eight epileptic patients receiving anticonvulsants had recurrent visual disturbances in the form of diplopia and oscillopsia in the horizontal or vertical planes. The symptoms could be ascribed to impaired vergence mechanisms, vertical nystagmus, or abnormalities of the vestibulo-ocular reflex. Other eye movements, such as pursuit and gaze-holding, were also affected, but did not lead to complaints. Episodes of visual disturbance were often preceded by prodromes of ocular or systemic discomfort, after which oscillopsia or diplopia evolve rapidly. The symptomatology was stereotyped but unique for each patient and may reflect idiosyncratic susceptibility to the ocular motor side effects of anticonvulsants. Six of the 8 patients were taking carbamazepine and phenytoin in combination, which have similar effects on the ocular motor system.
B F Remler; R J Leigh; I Osorio; R L Tomsak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  40     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-05-31     Completed Date:  1990-05-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  791-6     Citation Subset:  AIM; IM; S    
Department of Neurology, University Hospitals of Cleveland, OH 44106.
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MeSH Terms
Anticonvulsants / adverse effects*,  blood,  therapeutic use
Diplopia / chemically induced,  physiopathology
Epilepsy / complications,  drug therapy
Eye Movements / drug effects
Nystagmus, Pathologic / chemically induced,  physiopathology
Reflex, Vestibulo-Ocular / drug effects
Vision Disorders / chemically induced*
Grant Support
Reg. No./Substance:

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