| The characteristics and mechanisms of visual disturbance associated with anticonvulsant therapy. | |
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MedLine Citation:
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PMID: 2330106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eight epileptic patients receiving anticonvulsants had recurrent visual disturbances in the form of diplopia and oscillopsia in the horizontal or vertical planes. The symptoms could be ascribed to impaired vergence mechanisms, vertical nystagmus, or abnormalities of the vestibulo-ocular reflex. Other eye movements, such as pursuit and gaze-holding, were also affected, but did not lead to complaints. Episodes of visual disturbance were often preceded by prodromes of ocular or systemic discomfort, after which oscillopsia or diplopia evolve rapidly. The symptomatology was stereotyped but unique for each patient and may reflect idiosyncratic susceptibility to the ocular motor side effects of anticonvulsants. Six of the 8 patients were taking carbamazepine and phenytoin in combination, which have similar effects on the ocular motor system. |
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Authors:
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B F Remler; R J Leigh; I Osorio; R L Tomsak |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neurology Volume: 40 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1990 May |
Date Detail:
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Created Date: 1990-05-31 Completed Date: 1990-05-31 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 791-6 Citation Subset: AIM; IM; S |
Affiliation:
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Department of Neurology, University Hospitals of Cleveland, OH 44106. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anticonvulsants / adverse effects*, blood, therapeutic use Diplopia / chemically induced, physiopathology Epilepsy / complications, drug therapy Eye Movements / drug effects Female Humans Male Nystagmus, Pathologic / chemically induced, physiopathology Reflex, Vestibulo-Ocular / drug effects Vision Disorders / chemically induced* |
| Grant Support | |
ID/Acronym/Agency:
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EY06717/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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