| The characteristics and frequency of augmented breaths during CO2-induced hyperpnoea of newborn infants. | |
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MedLine Citation:
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PMID: 8821151 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Hypercapnic ventilatory responses of thirty-five full term infants aged 1-7 days were evaluated, and the characteristics and incidence of augmented breaths were determined. 2. According to the inspiratory airflow profile and tidal volume (VT), augmented breaths were categorized as 'type A' (biphasic, VT > or = 2 x control VT), or 'type M' (multiphasic, VT < 2 x control VT). 3. Steady-state inhalation of 2-4% CO2 resulted in a 3-fold increase in the frequency of augmented breaths after 8 min; 80 s rebreathing a mixture containing 5-6% CO2 resulted in a 20-fold increase in the frequency of these breaths. 4. During eupnoea, 85% of spontaneously occurring augmented breaths were type A. With increasing respiratory drive, there was a disproportionate increase in type M compared with type A breaths: after 80 s rebreathing, 86% of augmented breaths were type M and only 14% were type A. 5. These findings indicate that the hypercapnic hyperpnoea facilitates an inspiration-augmenting reflex in newborn infants. The significance of type M breaths is unclear; they appear to be characteristic of the newborn, and may represent the response of an immature respiratory system to load. |
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Authors:
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G Cohen; D J Henderson-Smart |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of physiology Volume: 490 ( Pt 2) ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 1996 Jan |
Date Detail:
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Created Date: 1996-11-06 Completed Date: 1996-11-06 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 551-7 Citation Subset: IM |
Affiliation:
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Department of Perinatal Medicine, King George V Hospital, Camperdown, NSW, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carbon Dioxide
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diagnostic use* Humans Hypercapnia Infant, Newborn / physiology* Pulmonary Ventilation / physiology Respiration / physiology* Respiratory Mechanics / physiology Retrospective Studies Sleep, REM / physiology Tidal Volume / physiology |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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