Document Detail


The characteristics of concomitant thyroid nodules cause false-positive ultrasonography results in primary hyperparathyroidism.
MedLine Citation:
PMID:  19563934     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Concomitant thyroid nodules are the most common reason for false-positive ultrasonography (US) results in primary hyperparathyroidism. The aims of this prospective clinical study were to evaluate false-positive US results according to the characteristics of concomitant thyroid nodules and to determine which characteristics of thyroid nodules are important. STUDY DESIGN: This prospective study included 120 consecutive patients with primary hyperparathyroidism. The patients were divided into 2 groups according to preoperative US results. Group 1 consisted of 32 patients with false-positive US results and group 2 consisted of 88 patients with true-positive US results. RESULTS: The risk for false-positive US result was increased 25-fold for patients with parathyroid adenoma weight of more than 500 mg (odds ratio [OR], 25; 95% confidence interval [CI], 8.6-74.5), 75-fold for more than 1 posteriorly located thyroid (OR, 75; 95% CI, 19.3-293.4), 358-fold for the presence of exophytic thyroid nodules (OR, 358; 95% CI, 42.3-3036), and 423-fold for the presence of posteriorly located thyroid nodules (OR, 423; 95% CI, 49-3662). CONCLUSION: Although there was no particular characteristic of concomitant thyroid nodules that contributes to false-positive US results, the posteriorly located thyroid nodules were the strongest correlate for the false-positive US results to other features.
Authors:
Umut Barbaros; Yeşim Erbil; Artür Salmashoğlu; Halim Işsever; Ferihan Aral; Mehtap Tunaci; Selçuk Ozarmağan
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-02-06
Journal Detail:
Title:  American journal of otolaryngology     Volume:  30     ISSN:  1532-818X     ISO Abbreviation:  Am J Otolaryngol     Publication Date:    2009 Jul-Aug
Date Detail:
Created Date:  2009-06-30     Completed Date:  2009-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000029     Medline TA:  Am J Otolaryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  239-43     Citation Subset:  IM    
Affiliation:
Department of Surgery, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Biopsy, Fine-Needle
Diagnosis, Differential
False Positive Reactions
Female
Follow-Up Studies
Humans
Hyperparathyroidism, Primary / complications,  surgery,  ultrasonography*
Male
Middle Aged
Parathyroid Glands / pathology,  ultrasonography
Parathyroidectomy / methods
Prognosis
Prospective Studies
Thyroid Gland / pathology,  ultrasonography
Thyroid Nodule / complications,  surgery,  ultrasonography*
Thyroidectomy / methods
Young Adult

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