Document Detail

The characteristics and clinical outcome of adult patients with aplastic anemia and abnormal cytogenetics at diagnosis.
MedLine Citation:
PMID:  20540166     Owner:  NLM     Status:  MEDLINE    
The characteristics and clinical outcome of 600 adult patients with aplastic anemia (AA) that had successful cytogenetic studies at the time of diagnosis were retrospectively evaluated. Among these, 572 (95.3%) had normal cytogenetics and 28 (4.7%) had abnormal cytogenetics. The most frequent abnormality was trisomy 8 (n = 15), followed by monosomy 7/deletion of 7q (n = 5), and deletion of 1q (n = 5). There were no statistically significant differences with respect to gender, hepatitis viral infection, paroxysmal nocturnal hemoglobinuria, or severity of disease between the patients in the normal and abnormal cytogenetics groups; however, the patients with abnormal cytogenetics were generally younger than those with normal cytogenetics (P < 0.001). Abnormal cytogenetics was associated with a higher cumulative leukemic transformation rate (P < 0.001) and lower leukemic transformation-free survival (P = 0.021). Furthermore, abnormal cytogenetics was an independent predictor of a poor response to immunosuppressive therapy (HR = 0.255; 95% CI = 0.077-0.839; P = 0.024). These analyses suggest that patients with AA and abnormal cytogenetics have different clinical characteristics compared to patients with AA and normal cytogenetics.
Sung-Yong Kim; Jong-Wook Lee; Sung-Eun Lee; Byung-Sik Cho; Myungshin Kim; Ki-Seong Eom; Yoo-Jin Kim; Hee-Je Kim; Seok Lee; Chang-Ki Min; Seok-Goo Cho; Dong-Wook Kim; Kyungja Han; Woo-Sung Min
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genes, chromosomes & cancer     Volume:  49     ISSN:  1098-2264     ISO Abbreviation:  Genes Chromosomes Cancer     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-14     Completed Date:  2010-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007329     Medline TA:  Genes Chromosomes Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  844-50     Citation Subset:  IM    
Copyright Information:
(c) 2010 Wiley-Liss, Inc.
Department of Hematology/Oncology, KonKuk University Hospital, KonKuk University, Seoul, Korea.
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MeSH Terms
Aged, 80 and over
Anemia, Aplastic / diagnosis,  genetics*,  therapy
Cell Transformation, Neoplastic*
Chromosome Aberrations*
Immunosuppressive Agents / therapeutic use
Middle Aged
Retrospective Studies
Survival Rate
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Immunosuppressive Agents

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