Document Detail


The characteristics and clinical outcome of adult patients with aplastic anemia and abnormal cytogenetics at diagnosis.
MedLine Citation:
PMID:  20540166     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The characteristics and clinical outcome of 600 adult patients with aplastic anemia (AA) that had successful cytogenetic studies at the time of diagnosis were retrospectively evaluated. Among these, 572 (95.3%) had normal cytogenetics and 28 (4.7%) had abnormal cytogenetics. The most frequent abnormality was trisomy 8 (n = 15), followed by monosomy 7/deletion of 7q (n = 5), and deletion of 1q (n = 5). There were no statistically significant differences with respect to gender, hepatitis viral infection, paroxysmal nocturnal hemoglobinuria, or severity of disease between the patients in the normal and abnormal cytogenetics groups; however, the patients with abnormal cytogenetics were generally younger than those with normal cytogenetics (P < 0.001). Abnormal cytogenetics was associated with a higher cumulative leukemic transformation rate (P < 0.001) and lower leukemic transformation-free survival (P = 0.021). Furthermore, abnormal cytogenetics was an independent predictor of a poor response to immunosuppressive therapy (HR = 0.255; 95% CI = 0.077-0.839; P = 0.024). These analyses suggest that patients with AA and abnormal cytogenetics have different clinical characteristics compared to patients with AA and normal cytogenetics.
Authors:
Sung-Yong Kim; Jong-Wook Lee; Sung-Eun Lee; Byung-Sik Cho; Myungshin Kim; Ki-Seong Eom; Yoo-Jin Kim; Hee-Je Kim; Seok Lee; Chang-Ki Min; Seok-Goo Cho; Dong-Wook Kim; Kyungja Han; Woo-Sung Min
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genes, chromosomes & cancer     Volume:  49     ISSN:  1098-2264     ISO Abbreviation:  Genes Chromosomes Cancer     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-07-14     Completed Date:  2010-10-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007329     Medline TA:  Genes Chromosomes Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  844-50     Citation Subset:  IM    
Copyright Information:
(c) 2010 Wiley-Liss, Inc.
Affiliation:
Department of Hematology/Oncology, KonKuk University Hospital, KonKuk University, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Anemia, Aplastic / diagnosis,  genetics*,  therapy
Cell Transformation, Neoplastic*
Chromosome Aberrations*
Female
Humans
Immunosuppressive Agents / therapeutic use
Karyotyping
Male
Middle Aged
Retrospective Studies
Survival Rate
Treatment Outcome
Trisomy
Young Adult
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents

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