| The characteristics and clinical outcome of adult patients with aplastic anemia and abnormal cytogenetics at diagnosis. | |
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MedLine Citation:
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PMID: 20540166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The characteristics and clinical outcome of 600 adult patients with aplastic anemia (AA) that had successful cytogenetic studies at the time of diagnosis were retrospectively evaluated. Among these, 572 (95.3%) had normal cytogenetics and 28 (4.7%) had abnormal cytogenetics. The most frequent abnormality was trisomy 8 (n = 15), followed by monosomy 7/deletion of 7q (n = 5), and deletion of 1q (n = 5). There were no statistically significant differences with respect to gender, hepatitis viral infection, paroxysmal nocturnal hemoglobinuria, or severity of disease between the patients in the normal and abnormal cytogenetics groups; however, the patients with abnormal cytogenetics were generally younger than those with normal cytogenetics (P < 0.001). Abnormal cytogenetics was associated with a higher cumulative leukemic transformation rate (P < 0.001) and lower leukemic transformation-free survival (P = 0.021). Furthermore, abnormal cytogenetics was an independent predictor of a poor response to immunosuppressive therapy (HR = 0.255; 95% CI = 0.077-0.839; P = 0.024). These analyses suggest that patients with AA and abnormal cytogenetics have different clinical characteristics compared to patients with AA and normal cytogenetics. |
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Authors:
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Sung-Yong Kim; Jong-Wook Lee; Sung-Eun Lee; Byung-Sik Cho; Myungshin Kim; Ki-Seong Eom; Yoo-Jin Kim; Hee-Je Kim; Seok Lee; Chang-Ki Min; Seok-Goo Cho; Dong-Wook Kim; Kyungja Han; Woo-Sung Min |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Genes, chromosomes & cancer Volume: 49 ISSN: 1098-2264 ISO Abbreviation: Genes Chromosomes Cancer Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-07-14 Completed Date: 2010-10-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007329 Medline TA: Genes Chromosomes Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 844-50 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Hematology/Oncology, KonKuk University Hospital, KonKuk University, Seoul, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Anemia, Aplastic / diagnosis, genetics*, therapy Cell Transformation, Neoplastic* Chromosome Aberrations* Female Humans Immunosuppressive Agents / therapeutic use Karyotyping Male Middle Aged Retrospective Studies Survival Rate Treatment Outcome Trisomy Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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