Document Detail

A characteristic cutaneous direct immunofluorescent pattern associated with Ro(SS-A) antibodies in subacute cutaneous lupus erythematosus.
MedLine Citation:
PMID:  1430355     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Antibodies to Ro(SS-A) are present in most patients with subacute cutaneous lupus erythematosus (SCLE). Patients with SCLE also have cutaneous immune deposits. However, no correlation of Ro(SS-A) antibodies with immune deposits in skin biopsy specimens has been described. OBJECTIVE: The purpose of this study is to describe characteristic direct immunofluorescence (IF) findings in 32 patients and their association with serum antibodies and clinical diagnosis. METHODS: Serum from patients with characteristic cutaneous direct IF findings was examined for antinuclear antibodies by indirect IF and for antibodies to ribonucleoprotein, Sm, Ro(SS-A), and La(SS-B) by gel immunodiffusion. RESULTS: Twenty-two of 32 patients who exhibited discrete speckled IgG staining predominantly, but not exclusively, of the basal cell cytoplasm had SCLE. Ro(SS-A) antibodies were identified in 23 of 26 patients and Ro(SS-A) and/or La(SS-B) in 25 of 26 patients. CONCLUSION: Direct IF staining characterized by discrete speckled IgG deposits in the basal cell cytoplasm is associated with Ro(SS-A) antibodies and SCLE.
J E Valeski; V Kumar; A B Forman; E H Beutner; T P Chorzelski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  27     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-12-07     Completed Date:  1992-12-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  194-8     Citation Subset:  IM    
IMMCO Diagnostics Inc., Buffalo, NY 14223.
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MeSH Terms
Acute Disease
Antibodies, Antinuclear / analysis*,  blood
Fluorescent Antibody Technique*
Immunoglobulin G / analysis
Lupus Erythematosus, Cutaneous / blood,  immunology*,  pathology
Skin / immunology*,  pathology
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Immunoglobulin G; 0/SS-A antibodies

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