Document Detail


The characterisation of gliomas using human monoclonal antibodies. Minireview on cancer research.
MedLine Citation:
PMID:  6386566     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Malignant gliomas contain large numbers of invading lymphocytes. The function of these lymphocytes is unknown. It is likely that they are involved in host defence against the developing tumour. By isolating these cells and fusing them with a suitable myeloma system, hybrids can be established and their antibody activity analysed. Human monoclonal antibodies reactive to glioma cells have now been isolated and their specificity has been determined by radioimmunoassay, binding assays and immunoprecipitation. Furthermore, such antibodies can be radiolabelled with 131I and administered intravenously to localise tumours in patients. These antibodies have therapeutic potential as selective targeting agents for chemotherapy and other cytotoxic agents.
Authors:
K Sikora
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Experimental cell biology     Volume:  52     ISSN:  0304-3568     ISO Abbreviation:  Exp. Cell Biol.     Publication Date:  1984  
Date Detail:
Created Date:  1984-11-28     Completed Date:  1984-11-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7701827     Medline TA:  Exp Cell Biol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  189-95     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Monoclonal / biosynthesis,  diagnostic use*
Antigens, Neoplasm / immunology
B-Lymphocytes / immunology*
Fluorescent Antibody Technique
Glioma / immunology*,  pathology,  radiography
Humans
Radioimmunoassay
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, Neoplasm

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