| The characterisation of gliomas using human monoclonal antibodies. Minireview on cancer research. | |
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MedLine Citation:
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PMID: 6386566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Malignant gliomas contain large numbers of invading lymphocytes. The function of these lymphocytes is unknown. It is likely that they are involved in host defence against the developing tumour. By isolating these cells and fusing them with a suitable myeloma system, hybrids can be established and their antibody activity analysed. Human monoclonal antibodies reactive to glioma cells have now been isolated and their specificity has been determined by radioimmunoassay, binding assays and immunoprecipitation. Furthermore, such antibodies can be radiolabelled with 131I and administered intravenously to localise tumours in patients. These antibodies have therapeutic potential as selective targeting agents for chemotherapy and other cytotoxic agents. |
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Authors:
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K Sikora |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Experimental cell biology Volume: 52 ISSN: 0304-3568 ISO Abbreviation: Exp. Cell Biol. Publication Date: 1984 |
Date Detail:
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Created Date: 1984-11-28 Completed Date: 1984-11-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7701827 Medline TA: Exp Cell Biol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 189-95 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Monoclonal
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biosynthesis,
diagnostic use* Antigens, Neoplasm / immunology B-Lymphocytes / immunology* Fluorescent Antibody Technique Glioma / immunology*, pathology, radiography Humans Radioimmunoassay Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Antigens, Neoplasm |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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