| The changing role of maternal thyroid hormone in fetal brain development. | |
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MedLine Citation:
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PMID: 19007674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review briefly summarizes: (1) the changes in maternal thyroid function that are imposed by the presence of the fetus and the high concentrations of human chorionic gonadotropin essential for the maintenance of the pregnancy, which result in high first trimester free thyroxine and triiodothyronine, requiring doubling of the iodine intake; (2) the changes in the fetal compartment up to midgestation, which result in increasing concentrations of triiodothyronine in the cerebral cortex generated locally from thyroxine by high activities of type 2 iodothyronine deiodinase; (3) the important role of the maternal contribution of thyroxine to the fetal circulation after onset of secretion of hormones by the fetal thyroid; and (4) the consequences of the interruption of the maternal supply of thyroid hormones that occur with prematurity. Efforts to devise appropriate strategies to avoid or shorten the postnatal hypothyroxinemia of infants born prematurely may well result in fewer and less severe neurodevelopmental deficits. |
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Authors:
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Gabriella Morreale de Escobar; Susana Ares; Pere Berbel; María Jesus Obregón; Francisco Escobar del Rey |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in perinatology Volume: 32 ISSN: 1558-075X ISO Abbreviation: Semin. Perinatol. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-14 Completed Date: 2009-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7801132 Medline TA: Semin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 380-6 Citation Subset: IM |
Affiliation:
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Instituto de Investigaciones Biomédicas Alberto Sols, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain. gmorreale@iib.uam.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / embryology* Female Fetal Development / physiology Fetus Humans Infant, Newborn Infant, Premature Iodine / administration & dosage, metabolism Pregnancy / physiology* Rats Thyroid Gland / physiology* Thyrotropin / physiology* Thyroxine / physiology* Triiodothyronine / physiology* |
| Chemical | |
Reg. No./Substance:
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6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 7553-56-2/Iodine; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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