Document Detail


The changing estrogen content of the nuclear fraction of human myometrium during labor.
MedLine Citation:
PMID:  7303029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The cytosol and nuclear fractions were prepared from 32 pieces of myometrium obtained from 20 elective cesarean sections (regarded as typical of quiescent pregnancy (P)) and 12 emergency cesareans (performed after labor had started and therefore taken as typical of labor (L)). The nuclear fraction was purified by standard procedures. All protein-bound estrogen was released from the nuclear fractions, and the released estrogen simultaneously solubilized by denaturation with ethanol. The estriol (E3) and estradiol (E2) content of the alcohol solutions were assayed by radioimmunoassay with highly specific antisera for E3 and E2. In the L group, average E3 content was slightly (not significantly) lower, and average E2 content was significantly (P less than 0.005) higher, than in the P group. The E3/E2 ratio decreased dramatically (P less than 0.001) during this change from P to L.
Authors:
H H Ko; S L Cohen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Steroids     Volume:  38     ISSN:  0039-128X     ISO Abbreviation:  Steroids     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1982-01-20     Completed Date:  1982-01-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404536     Medline TA:  Steroids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  175-84     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cell Nucleus / analysis*
Cytosol / analysis
Estradiol / analysis*
Estriol / analysis*
Female
Humans
Labor, Obstetric*
Myometrium / analysis*
Pregnancy
Radioimmunoassay
Uterus / analysis*
Chemical
Reg. No./Substance:
50-27-1/Estriol; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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