Document Detail

The changes of plasma endothelin in oleic acid-induced acute lung injury and their implication.
MedLine Citation:
PMID:  12840846     Owner:  NLM     Status:  MEDLINE    
The changes of pulmonary arterial and pulmonary venous plasma endothelin (ET) level in oleic acid (OA)--induced lung injury (ALI) rats were observed. After the ALI model of rats was established by intravenous injection of OA, blood samples were taken from a right cardiac catheter inserted via the right external jugular vein into the pulmonary artery to determine the plasma ET levels by using radioimmunoassay before OA injection, and 2 h and 4 h after OA injection. At the same time, arterial oxygen pressure (PaO2) and mean pulmonary arterial pressure (mPAP) were measured to evaluate the role of ET in acute lung injury. The results showed that the plasma ET levels after OA injection were significantly increased in OA group rats as compared with those in the controls, positively correlated with mPAP and negatively with PaO2. The plasma ET level in pulmonary vein was higher than in pulmonary artery, but no significant difference was found. It was concluded that ET, as a local or circulating hormone, might play an important role in pathophysiology of ALI.
X Liu; C Huang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Tongji Medical University = Tong ji yi ke da xue xue bao     Volume:  19     ISSN:  0257-716X     ISO Abbreviation:  J. Tongji Med. Univ.     Publication Date:  1999  
Date Detail:
Created Date:  2003-07-04     Completed Date:  2003-10-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8605495     Medline TA:  J Tongji Med Univ     Country:  China    
Other Details:
Languages:  eng     Pagination:  93-5     Citation Subset:  IM    
Department of Internal Medicine, Tongji Hospital, Tongji Medical University, Wuhan 430030.
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MeSH Terms
Blood Gas Monitoring, Transcutaneous
Endothelins / blood*
Oleic Acid
Pulmonary Artery / physiopathology
Random Allocation
Rats, Wistar
Respiratory Distress Syndrome, Adult / blood*,  chemically induced
Reg. No./Substance:
0/Endothelins; 112-80-1/Oleic Acid

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