| The changes in testicular vascular permeability during progression of the experimental varicocele. | |
| | |
MedLine Citation:
|
PMID: 12507549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: The vascular permeability of testicular capillaries which play a role in controlling the formation of testicular interstitial fluid was studied during the progressive course of experimental varicocele. MATERIALS AND METHODS: The pathology was developed through partial ligation of left renal vein in four groups of rats. Controls of each group were subjected to sham surgery. After different periods of varicocele creation (1, 3, 6 and 14 weeks), animals' testes per one of the study groups were extirpated and weighed. The volume density percentages of polymorphnuclear leukocytes (PMN) per testicular blood vessels; which are markers of the increase in vascular permeability, were also estimated in both testes. To further verify the obtained findings, another group of animals received human chorionic gonadotrophin (hCG) treatment 6 weeks after varicocele creation and their histopathological sections were examined. RESULTS: Animal testes' of (1 and 3 weeks) groups were found to be significantly heavier (p<0.05) than their controls. PMN showed accumulation in testicular blood vessels and their volume density percentages per these blood vessels in both testes were significantly higher in each study group than in those of its controls. However, these percentages showed gradual significant decline as the duration of varicocele bearing gradually increased. The hCG-treated animals revealed more accumulation of the PMN in their histopathological sections. CONCLUSION: The present results suggest that experimental varicocele may induce an increase in testicular vascular permeability, which then decreases gradually with time. It is supposed that parallel changes in the rate of formation of testicular interstitial fluid may be accompanied. The results have also showed that the vasculature of the testis with experimental varicocele can still respond to hCG. |
| | |
Authors:
|
Nader Salama; Anders Bergh; Jan-Erik Damber |
Related Documents
:
|
3547489 - Stop-type and shunt-type varicoceles: venographic findings. 10972559 - Varicocele and the testicular-renal venous route: hemodynamic doppler sonographic inves... 8564739 - Detection of the urine jet phenomenon using doppler color flow mapping. 17028819 - Doppler sonographic analysis of synovial vascularization in knee joints of patients wit... 12397719 - Enhanced color flows in hepatic tumors. 20676299 - A case of splenic torsion with progressive anemia and thrombocytopenia. 8676099 - Ultrasonography characterization of heart morphology and blood flow of lower vertebrates. 6971299 - Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man u... 1440719 - Experimental evidence of ischemic thresholds and functional recovery. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European urology Volume: 43 ISSN: 0302-2838 ISO Abbreviation: Eur. Urol. Publication Date: 2003 Jan |
Date Detail:
|
Created Date: 2002-12-31 Completed Date: 2003-07-29 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7512719 Medline TA: Eur Urol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 84-91 Citation Subset: IM |
Affiliation:
|
Department of Urology and Andrology, Umeå University, Umeå, Sweden. nadersalama@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Capillary Permeability* Disease Progression Male Rats Rats, Sprague-Dawley Testis / blood supply*, pathology Varicocele / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vesicoureteral reflux detected among patients with nocturnal enuresis.
Next Document: RING finger ubiquitin protein ligases: implications for tumorigenesis, metastasis and for molecular ...