| The changes in the expressions of gamma-aminobutyric acid transporters in the gerbil hippocampal complex following spontaneous seizure. | |
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MedLine Citation:
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PMID: 11524150 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To identify the roles of gamma-aminobutyric acid (GABA) transporter in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of GABA transporters (GAT) expression was conducted. GAT-1 immunoreactivity was more strongly detected in the pre-seizure group of seizure sensitive (SS) gerbils than that seen in the seizure resistant group. 30 min postictal, the density of GAT-1 immunoreactivity was significantly decreased in the hippocampal complex, as compared to pre-seizure group. 12 h after seizure on-set, the GAT immunodensity recovered to the pre-seizure level. Following the onset of seizure, GAT-3 immunoreactivity remained unchanged. These results suggest that the increase of GAT-1 expression in the SS gerbil hippocampus may affect epileptogenesis in this animal, and the alteration of immunoreactivity following seizure may be compensatory responses to modulate seizure activity. |
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Authors:
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T C Kang; H S Kim; M O Seo; S K Park; H Y Kwon; J H Kang; M H Won |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuroscience letters Volume: 310 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-08-28 Completed Date: 2001-10-25 Revised Date: 2006-11-20 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 29-32 Citation Subset: IM |
Affiliation:
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Department of Anatomy, College of Medicine, Hallym University, Chunchon, Kangwon-Do 200-702, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blotting, Western Carrier Proteins / biosynthesis* Dentate Gyrus / cytology, metabolism GABA Plasma Membrane Transport Proteins Gerbillinae Hippocampus / cytology, metabolism* Immunohistochemistry Membrane Proteins / biosynthesis* Membrane Transport Proteins* Organic Anion Transporters* Seizures / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/GABA Plasma Membrane Transport Proteins; 0/Membrane Proteins; 0/Membrane Transport Proteins; 0/Organic Anion Transporters |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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