Document Detail


The changes of cytokeratin 19 during oral carcinogenesis.
MedLine Citation:
PMID:  12419140     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the changes of cytokeratin 19 during oral carcinogenesis. METHODS: 53 specimens including normal oral mucosa, oral epithelial hyperplasia, oral epithelial dysplasia and oral squamous cell carcinoma were investigated by immunohistochemistry, SDS-PAGE and Western blotting. RESULTS: CK19 was detectable in suprabasal cell layers in epithelial dysplasia and in oral cancer, especially in poor-differentiated cancerous cells. With the lesions getting worse, the positive rate, the intensity and the constituent ratio of CK19 raised significantly. CONCLUSIONS: The results suggest that the CK19 expression in suprabasal cell layers of oral mucosa can be used as a marker of diagnosis of oral precancerous lesions and CK19 expression is the initial events during oral carcinogenesis.
Authors:
Minhai Nie; Li Zhong; Guangming Zeng; Bingqi Li
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology     Volume:  37     ISSN:  1002-0098     ISO Abbreviation:  Zhonghua Kou Qiang Yi Xue Za Zhi     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-11-06     Completed Date:  2002-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8711066     Medline TA:  Zhonghua Kou Qiang Yi Xue Za Zhi     Country:  China    
Other Details:
Languages:  eng     Pagination:  187-90     Citation Subset:  D; IM    
Affiliation:
Department of Oral Medicine, Hospital Affiliated to Luzhou Medical College, Luzhou Sichuan 646000, China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blotting, Western
Female
Humans
Immunohistochemistry
Keratins / analysis*
Male
Middle Aged
Mouth Mucosa / metabolism,  pathology*
Mouth Neoplasms / metabolism,  pathology*
Precancerous Conditions / metabolism,  pathology*
Chemical
Reg. No./Substance:
68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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