| The changes of cytokeratin 19 during oral carcinogenesis. | |
MedLine Citation:
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PMID: 12419140 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the changes of cytokeratin 19 during oral carcinogenesis. METHODS: 53 specimens including normal oral mucosa, oral epithelial hyperplasia, oral epithelial dysplasia and oral squamous cell carcinoma were investigated by immunohistochemistry, SDS-PAGE and Western blotting. RESULTS: CK19 was detectable in suprabasal cell layers in epithelial dysplasia and in oral cancer, especially in poor-differentiated cancerous cells. With the lesions getting worse, the positive rate, the intensity and the constituent ratio of CK19 raised significantly. CONCLUSIONS: The results suggest that the CK19 expression in suprabasal cell layers of oral mucosa can be used as a marker of diagnosis of oral precancerous lesions and CK19 expression is the initial events during oral carcinogenesis. |
Authors:
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Minhai Nie; Li Zhong; Guangming Zeng; Bingqi Li |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology Volume: 37 ISSN: 1002-0098 ISO Abbreviation: Zhonghua Kou Qiang Yi Xue Za Zhi Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-11-06 Completed Date: 2002-12-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8711066 Medline TA: Zhonghua Kou Qiang Yi Xue Za Zhi Country: China |
Other Details:
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Languages: eng Pagination: 187-90 Citation Subset: D; IM |
Affiliation:
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Department of Oral Medicine, Hospital Affiliated to Luzhou Medical College, Luzhou Sichuan 646000, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blotting, Western Female Humans Immunohistochemistry Keratins / analysis* Male Middle Aged Mouth Mucosa / metabolism, pathology* Mouth Neoplasms / metabolism, pathology* Precancerous Conditions / metabolism, pathology* |
| Chemical | |
Reg. No./Substance:
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68238-35-7/Keratins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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