Document Detail

The change of periapical exudate prostaglandin E2 levels during root canal treatment.
MedLine Citation:
PMID:  9487853     Owner:  NLM     Status:  MEDLINE    
We have previously demonstrated that detectable levels of prostaglandin E2 exist in periapical exudates (PE-PGE2) from root canals of periapical periodontitis. Our data from a cross-sectional study also suggested the association of PE-PGE2 concentrations with the active phase of periapical lesions. The objective of this study was to investigate the longitudinal changes of PE-PGE2 levels during root canal treatment. Periapical exudate specimens were quantitatively sampled from root canals of 20 nonvital teeth at consecutive treatment visits to measure PGE2 concentrations. The mean PE-PGE2 levels significantly decreased following the endodontic therapy (158.0 +/- 54.1 pg/microliter in the first samples versus 48.4 +/- 37.9 pg/microliter in the second samples). A significant correlation was also found between the changes in PE-PGE2 levels and the clinical disease expression of periapical periodontitis (p < 0.01). Decreased PGE2 production is considered to reflect the remission of disease activity. These results suggest the central roles of PGE2 in regulatory mechanisms for the expression of periapical disease.
H Shimauchi; S Takayama; Y Miki; H Okada
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of endodontics     Volume:  23     ISSN:  0099-2399     ISO Abbreviation:  J Endod     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-07-20     Completed Date:  1998-07-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7511484     Medline TA:  J Endod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  755-8     Citation Subset:  D    
Department of Periodontology and Endodontology, Osaka University Faculty of Dentistry, Japan.
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MeSH Terms
Dental Pulp Cavity
Dinoprostone / analysis*
Exudates and Transudates / chemistry*
Periapical Periodontitis / metabolism,  therapy
Periapical Tissue / chemistry*
Root Canal Therapy*
Reg. No./Substance:

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