Document Detail


The champions' mitochondria: Is it genetically determined? A review on mitochondrial DNA and elite athletic performance.
MedLine Citation:
PMID:  21540298     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aerobic ATP generation by the mitochondrial respiratory oxidative phosphorylation system (OXPHOS) is a vital metabolic process for endurance exercise. Notably, mitochondrial DNA (mtDNA) codifies 13 out of the 83 polypeptides implied in the respiratory chain. As such, there is a strong rationale for identifing an association between mtDNA variants and 'aerobic' (endurance) exercise phenotypes. This review aim is to summarise the current knowledge on the association between mtDNA, nuclear genes involved in mitochondriogenesis, and elite endurance athletic status. Several studies in non-athletic people have demonstrated an association between certain mtDNA lineages and aerobic performance, charecterized by maximal oxygen uptake (VO(2)max). Whether mtDNA haplogroups are also associated with the status of being an elite endurance athlete is more controversial, with differences between studies arising from the different ethnic background of the athletic cohorts (Caucasian of mixed geografic origin, Asiatic or East-African).
Authors:
Nir Eynon; Maria Moran; Ruth Birk; Alejandro Lucia
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-3
Journal Detail:
Title:  Physiological genomics     Volume:  -     ISSN:  1531-2267     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815683     Medline TA:  Physiol Genomics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Ariel University Center, Israel.
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