| The challenges in artificial muscle research to treat incontinence. | |
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MedLine Citation:
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PMID: 19918697 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sphincters to guarantee continence are in principal the simplest muscles, because only two states (closed and open) seem to be important. The healthy urinary sphincter, however, provides dynamic components. During the filling phase the increase in tonus prevents urinary loss. The sphincter rapidly responds to pressure pulses caused, for example, by coughing. Contemporary artificial sphincters, however, merely generate two states and often induce atrophy and erosion. Hence the success of commercially available, continually improved implants is still limited. This communication reviews two physical principles, shape memory alloys and electrically activated polymer nanostructures, for applications in artificial sphincters which adapt the pressure acting on the urethra and react to stress situations such as coughing. The application of these principles allows intermittent reduction of pressure on the urethra, thus involving significantly less atrophy. The fabrication of reliably working nanostructures, however, is ambitious and will need time-consuming, high-level engineering. |
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Authors:
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Bert Müller; Hans Deyhle; Shpend Mushkolaj; Marco Wieland |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Swiss medical weekly Volume: 139 ISSN: 1424-7860 ISO Abbreviation: Swiss Med Wkly Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-11-17 Completed Date: 2009-12-18 Revised Date: 2011-02-15 |
Medline Journal Info:
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Nlm Unique ID: 100970884 Medline TA: Swiss Med Wkly Country: Switzerland |
Other Details:
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Languages: eng Pagination: 591-5 Citation Subset: IM |
Affiliation:
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Biomaterials Science Center, University of Basel, c/o University Hospital Basel, Basel, Switzerland. bert.mueller@unibas.ch |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alloys Equipment Design Humans Nanotechnology* Polymers Urinary Incontinence / therapy* Urinary Sphincter, Artificial* |
| Chemical | |
Reg. No./Substance:
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0/Alloys; 0/Polymers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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