Document Detail

The challenges of chronic total coronary occlusions: an old problem in a new perspective.
MedLine Citation:
PMID:  15318898     Owner:  NLM     Status:  MEDLINE    
In spite of the remarkable technological innovation and improved outcomes with percutaneous coronary revascularization, chronic coronary artery total occlusions remain a familiar source of procedural frustration and clinical uncertainty. However, considering the recent development of catheter-based technologies specific for chronic total occlusion (CTO) recanalization and the potential for drug-eluting stents to reduce restenosis and reocclusion, this challenging lesion subset is now recognized as the last formidable barrier to percutaneous revascularization success. Further, consistent observations from more recent clinical trials support successful CTO revascularization to avoid subsequent adverse cardiac events and improve long-term overall survival. This review of total coronary occlusions provides an overview of CTO pathophysiology, describes the procedural and clinical outcomes associated with CTO revascularization, and presents future directions for clinical investigation.
David E Kandzari
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of interventional cardiology     Volume:  17     ISSN:  0896-4327     ISO Abbreviation:  J Interv Cardiol     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-20     Completed Date:  2004-10-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8907826     Medline TA:  J Interv Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  259-67     Citation Subset:  IM    
Division of Cardiology, Duke University Medical Center and Duke Clinical Research Institute, 2400 Pratt Street, Durham, NC 27705, U.S.A.
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MeSH Terms
Angioplasty, Balloon / instrumentation
Arteriosclerosis / physiopathology,  therapy*
Catheterization / instrumentation
Chronic Disease
Coronary Vessels / pathology*
Myocardial Revascularization / instrumentation,  methods*

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