Document Detail


The challenge of chloroquine-resistant malaria in sub-Saharan Africa.
MedLine Citation:
PMID:  11238424     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
For the last decade chloroquine-resistant Plasmodium falciparum (CRPF) has spread explosively in sub-Saharan Africa. In some areas of the continent, CRPF is so intense that chloroquine can hardly be said to have any efficacy. There is emerging evidence that CRPF is linked with increased incidence of mortality, severe disease and emergence of epidemics. Whereas the normal response to this trend of events would be replacing chloroquine with another effective drug, such a decision is hampered by the limited number of antimalarials currently available. There is a fear that changing too early would lead to depletion of available drugs. Yet a delay may be costly and catastrophic. Since the development of new antimalarials is deemed commercially unviable by high-income countries, there is need for a pan-African project aimed at the development of new antimalarials. Such a project could be jointly funded from African governments and the donor community under the coordination of either the World Health Organization or the Organization of African Unity. To delay the emergence and spread of resistance by P. falciparum to new and old drugs, there is need for: improving rational drugs use; limiting mass use of drugs as in chemoprophylaxis and in medicated salt; and increasing the use of impregnated bed nets.
Authors:
F Nuwaha
Related Documents :
19149664 - Fighting against leishmaniasis: search of alkaloids as future true potential anti-leish...
1575774 - Hemin-catalyzed decomposition of artemisinin (qinghaosu).
14516924 - Comparison between two common methods for measuring giardia lamblia susceptibility to a...
316734 - Use of drugs for malaria control in tropical africa.
19372974 - Drug interactions between statins and antiretroviral agents.
16307454 - A rabbit model for sublingual drug delivery: comparison with human pharmacokinetic stud...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Health policy and planning     Volume:  16     ISSN:  0268-1080     ISO Abbreviation:  Health Policy Plan     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-12     Completed Date:  2001-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610614     Medline TA:  Health Policy Plan     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-12     Citation Subset:  H    
Affiliation:
Department of Community Health, Mbarara University, Mbarara, Uganda. mustmed@infocom.co.ug
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Africa South of the Sahara / epidemiology
Animals
Antimalarials / supply & distribution,  therapeutic use*
Chloroquine / supply & distribution,  therapeutic use*
Developing Countries
Disease Outbreaks / prevention & control
Drug Resistance
Humans
Malaria, Falciparum / drug therapy*,  epidemiology,  prevention & control*
Plasmodium falciparum / drug effects*
Chemical
Reg. No./Substance:
0/Antimalarials; 54-05-7/Chloroquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Determination of the number of conserved chromosomal segments between species.
Next Document:  Ten recommendations to improve use of medicines in developing countries.