Document Detail

The challenge of chloroquine-resistant malaria in sub-Saharan Africa.
MedLine Citation:
PMID:  11238424     Owner:  NLM     Status:  MEDLINE    
For the last decade chloroquine-resistant Plasmodium falciparum (CRPF) has spread explosively in sub-Saharan Africa. In some areas of the continent, CRPF is so intense that chloroquine can hardly be said to have any efficacy. There is emerging evidence that CRPF is linked with increased incidence of mortality, severe disease and emergence of epidemics. Whereas the normal response to this trend of events would be replacing chloroquine with another effective drug, such a decision is hampered by the limited number of antimalarials currently available. There is a fear that changing too early would lead to depletion of available drugs. Yet a delay may be costly and catastrophic. Since the development of new antimalarials is deemed commercially unviable by high-income countries, there is need for a pan-African project aimed at the development of new antimalarials. Such a project could be jointly funded from African governments and the donor community under the coordination of either the World Health Organization or the Organization of African Unity. To delay the emergence and spread of resistance by P. falciparum to new and old drugs, there is need for: improving rational drugs use; limiting mass use of drugs as in chemoprophylaxis and in medicated salt; and increasing the use of impregnated bed nets.
F Nuwaha
Related Documents :
6976854 - New tissue schizontocidal antimalarial drugs.
8256104 - Malaria and travelers--practical aspects.
20144934 - Oral artesunate for neonatal malaria.
12758284 - Lipid metabolism in plasmodium falciparum-infected erythrocytes: possible new targets f...
3833814 - The association of preexisting psychosocial pathology with deaths involving propoxyphen...
15601444 - Pharmacokinetic/pharmacodynamic relationships of antimicrobial drugs used in veterinary...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Health policy and planning     Volume:  16     ISSN:  0268-1080     ISO Abbreviation:  Health Policy Plan     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-12     Completed Date:  2001-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610614     Medline TA:  Health Policy Plan     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-12     Citation Subset:  H    
Department of Community Health, Mbarara University, Mbarara, Uganda.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Africa South of the Sahara / epidemiology
Antimalarials / supply & distribution,  therapeutic use*
Chloroquine / supply & distribution,  therapeutic use*
Developing Countries
Disease Outbreaks / prevention & control
Drug Resistance
Malaria, Falciparum / drug therapy*,  epidemiology,  prevention & control*
Plasmodium falciparum / drug effects*
Reg. No./Substance:
0/Antimalarials; 54-05-7/Chloroquine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Determination of the number of conserved chromosomal segments between species.
Next Document:  Ten recommendations to improve use of medicines in developing countries.