Document Detail

The cerebrospinal fluid in patients with moyamoya disease (spontaneous occlusion of the circle of Willis) contains high level of basic fibroblast growth factor.
MedLine Citation:
PMID:  8247356     Owner:  NLM     Status:  MEDLINE    
The level of basic fibroblast growth factor (bFGF) in cerebrospinal fluid (CF) was measured by an EIA in 15 patients with moyamoya disease, in 11 patients with atherosclerotic occlusive disease, and in 8 patients with spinal disc disease. In the moyamoya patients, bFGF was found in 13 out of 15 CF samples with a mean value of 101 pg/ml. However, bFGF was detected in only 4 out of 11 patients with atherosclerotic disease with a mean of 8 pg/ml. In all the patients with disc disease, bFGF was not detected. The elevated level of bFGF may play a crucial role in the pathogenesis of moyamoya disease.
A Takahashi; Y Sawamura; K Houkin; H Kamiyama; H Abe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  160     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-01-04     Completed Date:  1994-01-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  214-6     Citation Subset:  IM    
Department of Neurosurgery, Hokkaido University School of Medicine, Sapporo, Japan.
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MeSH Terms
Antibodies, Monoclonal
Arterial Occlusive Diseases / cerebrospinal fluid
Biological Markers / cerebrospinal fluid
Cerebrovascular Disorders / etiology
Fibroblast Growth Factor 2 / cerebrospinal fluid*
Immunoenzyme Techniques
Moyamoya Disease / cerebrospinal fluid*,  surgery
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Biological Markers; 103107-01-3/Fibroblast Growth Factor 2

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