Document Detail


Is cerebral palsy preventable?
MedLine Citation:
PMID:  18317269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: To use evidence of good medical quality to update information on strategies for prevention of cerebral palsy, and on the success of these preventive efforts to date.
RECENT FINDINGS: Causes of cerebral palsy, and therefore promising approaches to prevention, differ by gestational age group and by clinical subtype. Neuroimaging and neuropathology indicate the importance of white matter disorders and of ischemic stroke in cerebral palsy; birth asphyxia, congenital malformations, placental pathology, and genetic variants also contribute to cerebral palsy risk. Multiplicity of risk factors markedly increases risk. Recent studies indicate that mild hypothermia lessens cerebral palsy risk in term infants with moderate neonatal encephalopathy, and the possibility that administration of magnesium sulphate to women in preterm labor may aid in primary prevention of cerebral palsy in very preterm infants.
SUMMARY: Past efforts to prevent cerebral palsy have not had the benefits sought, but recent results provide new hope and new challenges.
Authors:
Karin B Nelson; Taeun Chang
Related Documents :
11517109 - Hypertension and facial palsy in middle aortic syndrome.
20844159 - Onabotulinum toxina injection as an adjunct in the treatment of posterior shoulder subl...
11593379 - Bilateral thalamic lesions in a newborn with intrauterine asphyxia after maternal cardi...
10987569 - Infection, inflammation and the risk of cerebral palsy.
21319279 - Health outcomes among infants born to women deployed to united states military operatio...
3978989 - Investigation of cerebral energy metabolism in newborn infants by phosphorus nuclear ma...
11236409 - Sudden infant death syndrome, maternal smoking during pregnancy, and the cost-effective...
7629659 - Thermal analyser and micro ft-ir/dsc system used to determine the protective ability of...
19068999 - Tsunami: a history of the term and of scientific understanding of the phenomenon in jap...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review    
Journal Detail:
Title:  Current opinion in neurology     Volume:  21     ISSN:  1350-7540     ISO Abbreviation:  Curr. Opin. Neurol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-10     Completed Date:  2008-06-13     Revised Date:  2013-01-18    
Medline Journal Info:
Nlm Unique ID:  9319162     Medline TA:  Curr Opin Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  129-35     Citation Subset:  IM    
Affiliation:
National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892-2540, USA. knelson@helix.nih.gov
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Asphyxia Neonatorum / complications,  physiopathology,  prevention & control
Brain / abnormalities*,  growth & development,  physiopathology
Cerebral Palsy / etiology*,  physiopathology,  prevention & control*
Encephalitis / complications,  physiopathology,  prevention & control
Genetic Predisposition to Disease / genetics
Humans
Hypoxia-Ischemia, Brain / complications,  physiopathology,  prevention & control
Infant, Newborn
Nervous System Malformations / pathology,  physiopathology
Premature Birth / physiopathology
Stroke / complications,  physiopathology,  prevention & control

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Neurodevelopmental outcomes of preterm infants.
Next Document:  Health and well being of adults with cerebral palsy.