Document Detail

Is cerebral palsy preventable?
MedLine Citation:
PMID:  18317269     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: To use evidence of good medical quality to update information on strategies for prevention of cerebral palsy, and on the success of these preventive efforts to date.
RECENT FINDINGS: Causes of cerebral palsy, and therefore promising approaches to prevention, differ by gestational age group and by clinical subtype. Neuroimaging and neuropathology indicate the importance of white matter disorders and of ischemic stroke in cerebral palsy; birth asphyxia, congenital malformations, placental pathology, and genetic variants also contribute to cerebral palsy risk. Multiplicity of risk factors markedly increases risk. Recent studies indicate that mild hypothermia lessens cerebral palsy risk in term infants with moderate neonatal encephalopathy, and the possibility that administration of magnesium sulphate to women in preterm labor may aid in primary prevention of cerebral palsy in very preterm infants.
SUMMARY: Past efforts to prevent cerebral palsy have not had the benefits sought, but recent results provide new hope and new challenges.
Karin B Nelson; Taeun Chang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review    
Journal Detail:
Title:  Current opinion in neurology     Volume:  21     ISSN:  1350-7540     ISO Abbreviation:  Curr. Opin. Neurol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-10     Completed Date:  2008-06-13     Revised Date:  2013-01-18    
Medline Journal Info:
Nlm Unique ID:  9319162     Medline TA:  Curr Opin Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  129-35     Citation Subset:  IM    
National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892-2540, USA.
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MeSH Terms
Asphyxia Neonatorum / complications,  physiopathology,  prevention & control
Brain / abnormalities*,  growth & development,  physiopathology
Cerebral Palsy / etiology*,  physiopathology,  prevention & control*
Encephalitis / complications,  physiopathology,  prevention & control
Genetic Predisposition to Disease / genetics
Hypoxia-Ischemia, Brain / complications,  physiopathology,  prevention & control
Infant, Newborn
Nervous System Malformations / pathology,  physiopathology
Premature Birth / physiopathology
Stroke / complications,  physiopathology,  prevention & control

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