Document Detail


The cerebral metabolism of glucose and oxygen measured with positron tomography in patients with mitochondrial diseases.
MedLine Citation:
PMID:  3263167     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cerebral oxygen and glucose metabolism have been studied in 8 patients with biochemically defined mitochondrial myopathies and 7 normal control subjects using positron emission tomography. Four patients had myopathy alone and 4 had predominantly central nervous system (CNS) disease. Cerebral oxygen and glucose metabolism were measured concurrently in the two groups of patients with 15O, 11C and 18F labelled tracers and positron emission tomography (PET). Patients with major CNS disease showed an uncoupling of glucose and oxygen metabolism when compared with patients without cerebral disease and normal subjects. The mean ratio between oxygen and glucose utilization was 3.8 moles of oxygen per mole of glucose in patients with CNS disease, compared with 5.6 for controls and 6.4 for patients with myopathy alone. The altered stoichiometry in CNS cases indicates aerobic glycolysis to lactate and/or other intermediate metabolites. Patients with major CNS disease showed a 50% reduction in cerebral oxygen utilization compared with cerebrally unaffected patients and normal subjects. These findings indicate that in patients with a mitochondrial encephalopathy the defect identified in skeletal muscle is also expressed in the brain.
Authors:
R S Frackowiak; S Herold; R K Petty; J A Morgan-Hughes
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain : a journal of neurology     Volume:  111 ( Pt 5)     ISSN:  0006-8950     ISO Abbreviation:  Brain     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-12-14     Completed Date:  1988-12-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372537     Medline TA:  Brain     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1009-24     Citation Subset:  AIM; IM    
Affiliation:
MRC Cyclotron Unit, Hammersmith Hospital, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / metabolism*,  radionuclide imaging
Brain Diseases / complications
Central Nervous System Diseases / complications,  metabolism
Deoxyglucose / analogs & derivatives,  diagnostic use
Female
Fluorodeoxyglucose F18
Glucose / metabolism*
Humans
Male
Metabolism, Inborn Errors / complications,  metabolism*,  radionuclide imaging
Middle Aged
Mitochondria, Muscle / metabolism*
Oxygen Consumption*
Reference Values
Tomography, Emission-Computed*
Chemical
Reg. No./Substance:
154-17-6/Deoxyglucose; 50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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