| The cerebral effects of ascent to high altitudes. | |
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MedLine Citation:
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PMID: 19161909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cellular hypoxia is the common final pathway of brain injury that occurs not just after asphyxia, but also when cerebral perfusion is impaired directly (eg, embolic stroke) or indirectly (eg, raised intracranial pressure after head injury). We Review recent advances in the understanding of neurological clinical syndromes that occur on exposure to high altitudes, including high altitude headache (HAH), acute mountain sickness (AMS), and high altitude cerebral oedema (HACE), and the genetics, molecular mechanisms, and physiology that underpin them. We also present the vasogenic and cytotoxic bases for HACE and explore venous hypertension as a possible contributory factor. Although the factors that control susceptibility to HACE are poorly understood, the effects of exposure to altitude (and thus hypobaric hypoxia) might provide a reproducible model for the study of cerebral cellular hypoxia in healthy individuals. The effects of hypobaric hypoxia might also provide new insights into the understanding of hypoxia in the clinical setting. |
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Authors:
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Mark H Wilson; Stanton Newman; Chris H Imray |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Lancet neurology Volume: 8 ISSN: 1474-4422 ISO Abbreviation: Lancet Neurol Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-23 Completed Date: 2009-03-13 Revised Date: 2009-07-02 |
Medline Journal Info:
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Nlm Unique ID: 101139309 Medline TA: Lancet Neurol Country: England |
Other Details:
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Languages: eng Pagination: 175-91 Citation Subset: IM |
Affiliation:
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Centre for Altitude, Space and Extreme Environment Medicine, University College London, London, UK. mark@rcsed.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Air Pressure Altitude Sickness / drug therapy, genetics, physiopathology*, psychology Anoxia / physiopathology Brain Edema / etiology, physiopathology Cerebrovascular Circulation / physiology* Child Chronic Disease Headache / etiology, physiopathology Humans Psychomotor Performance / physiology |
| Comments/Corrections | |
Comment In:
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Lancet Neurol. 2009 Jul;8(7):604-5; author reply 605
[PMID:
19539232
]
Lancet Neurol. 2009 Jul;8(7):604; author reply 605 [PMID: 19539231 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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