| The cerebral critical oxygen threshold of ventilated preterm lambs and the influence of antenatal inflammation. | |
| | |
MedLine Citation:
|
PMID: 21719723 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: Perinatal inflammation is associated with adverse neurodevelopmental outcomes which maybe partly due to changes in the cerebral oxygen delivery/consumption relationship. We aimed to determine the critical oxygen delivery threshold of the brain of neonatal preterm ventilated lambs and to determine if the critical threshold is affected by exposure to inflammation in utero. Method: Pregnant ewes received intra-amniotic injection of lipopolysaccharide (LPS) or saline at 125 d or 127 d gestation. Pulmonary and systemic flow-probes and catheters were surgically positioned in the fetus immediately prior to delivery at 129 d gestation. After delivery, lambs were ventilated for 90 min using a PEEP recruitment strategy. Cardiorespiratory variables and blood gases were measured regularly. Systemic and cerebral oxygen delivery, consumption (Fick) and extraction were calculated and the relationship between cerebral delivery and consumption analysed. Linear regression was used to define the transition or 'critical' oxygen threshold as the point at which the slope of the oxygen/consumption curve changed to be >10 degrees. Four subgroups were defined according to the calculated critical threshold. Results: A total of 150 measurements were recorded in 18 lambs. Fetal cerebral oxygen consumption was increased by antenatal LPS (p<0.05). The postnatal critical oxygen threshold was 3.6 mL/kg/min corresponding to cerebral oxygen consumption of 0.73 mL/kg/min. High oxygen delivery and consumption was associated with increased pulmonary and carotid blood flow and systemic extraction compared with low oxygen delivery and consumption. No postnatal effect of antenatal inflammation was observed. |
| | |
Authors:
|
Chad C Andersen; J Jane Pillow; Andrew W Gill; Beth J Allison; Timothy Jm Moss; Stuart B Hooper; Ilias Nitsos; Martin Kluckow; Graeme R Polglase |
Related Documents
:
|
16219913 - Renal medullary tissue oxygenation is dependent on both cortical and medullary blood flow. 1273603 - Assessment of intrarenal perfusion with radioxenon: a critical review of analytical fac... 19874283 - The aachen miniaturized heart-lung machine--first results in a small animal model. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-30 |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-7-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1Women's and Children's Hospital. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Depressed contractile performance and reduced fatigue resistance in single skinned fibers of soleus ...
Next Document: MicroRNA 132 alters sleep and varies with time in brain.