Document Detail

Is cerebral autoregulation impaired in Parkinson's disease? A transcranial Doppler study.
MedLine Citation:
PMID:  17275849     Owner:  NLM     Status:  MEDLINE    
Orthostatic hypotension (OH) is one of the many autonomic disturbances observed in Parkinson's disease (PD). It has been debated whether an additional impairment of cerebral autoregulation (CA) in PD patients may exacerbate the consequences of OH upon brain perfusion. We assessed CA in PD patients and the potential influence of dopaminergic agents. CA was determined by means of transcranial Doppler (TCD) monitoring of the middle cerebral artery (MCA) at rest and during a thigh cuff release test inducing a systemic blood pressure (BP) drop. Fourteen patients were investigated when taking their usual dopaminergic medication and after drug discontinuation for 12 h. A control group was composed of 11 age-matched subjects (CS). In comparison with PD patients, CS presented a significantly higher increase of the mean cerebral blood flow velocities in the MCA after the BP drop. Mean velocities were increased above the initial values in all CS, whereas a flattened curve was observed in PD patients. No significant differences could be further observed between the PD patients regarding the BP, the cerebrovascular resistance, the heart rate and the pulsatility index. These results provide evidence of an impaired cerebral autoregulation in PD patients which appears independent of dopaminergic treatment.
N Vokatch; H Grötzsch; B Mermillod; P R Burkhard; R Sztajzel
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Publication Detail:
Type:  Journal Article     Date:  2007-02-02
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  254     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-06     Completed Date:  2007-05-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  49-53     Citation Subset:  IM    
Department of Neurology, Geneva University Hospitals and Medical School, Switzerland.
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MeSH Terms
Aged, 80 and over
Autonomic Dysreflexia / etiology,  physiopathology
Blood Flow Velocity
Blood Pressure / drug effects,  physiology
Brain Ischemia / etiology,  physiopathology,  ultrasonography*
Cerebral Arteries / physiopathology,  ultrasonography*
Cerebrovascular Circulation / drug effects,  physiology*
Dopamine Agents / adverse effects,  therapeutic use
Homeostasis / drug effects,  physiology
Middle Aged
Parkinson Disease / complications,  physiopathology,  ultrasonography*
Predictive Value of Tests
Shy-Drager Syndrome / etiology,  physiopathology,  ultrasonography*
Ultrasonography, Doppler, Transcranial
Reg. No./Substance:
0/Dopamine Agents

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