Document Detail


Is cerebral arteritis the cause of the Landau-Kleffner syndrome? Four cases in childhood with angiographic study.
MedLine Citation:
PMID:  1373338     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four children with Landau-Kleffner syndrome were studied over a six year period. They presented with acquired aphasia, epilepsy, and focal or generalized EEG discharges which were exacerbated during sleep. In addition, cerebral angiography demonstrated isolated arteritis of some branches of the carotid arteries in all cases. Computed tomographic and magnetic resonance images were normal. Nicardipine in a dose of 1 to 2 mg/kg/day, added to conventional anticonvulsant drugs provided effective supplementary control of seizures, of paroxysmal EEG discharges, and of language and behavioural disturbances, even several years after the onset of the disorder and in patients whose response to other medications, including steroids, had been poor. Interruption of nicardipine administration was followed by relapse of the language disorder. Repeat angiography was performed in all four patients and showed recanalization of obstructed vessels in two cases. Focal cerebral vasculitis may be the pathogenesis of the Landau-Kleffner syndrome and calcium channel blockers such as nicardipine may be effective and specific therapy.
Authors:
I Pascual-Castroviejo; V López Martín; A Martínez Bermejo; A Pérez Higueras
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques     Volume:  19     ISSN:  0317-1671     ISO Abbreviation:  Can J Neurol Sci     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-05-20     Completed Date:  1992-05-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0415227     Medline TA:  Can J Neurol Sci     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  46-52     Citation Subset:  IM    
Affiliation:
Department of Paediatric Neurology, Hospital Infantil La Paz, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Aphasia / drug therapy,  etiology*
Arteritis / complications*,  drug therapy
Cerebral Angiography
Cerebral Arteries*
Child
Electroencephalography
Female
Humans
Male
Nicardipine / therapeutic use
Seizures / drug therapy,  etiology*
Syndrome
Chemical
Reg. No./Substance:
55985-32-5/Nicardipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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